PerkinElmer

Radiochemicals

OF

Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.

Our radiochemical analysis products include:

  • Radionuclides such as 124I, 14C, 89Zr, 90Y, 125I, 131I, 22Na, 32P, 33P, 35S, 3H, 45Ca, 51Cr, 54Mn, 55Fe, 59Fe, 85Sr, 86Rb
  • EasyTag protein labeling mixes
  • EasyTide radiolabeled nucleotides
  • NEN radiolabeled compounds
  • SPA Enzymatic assays and imaging beads

Our radiolabeled compounds are useful in a wide range of applications:

  • Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
  • Kinetic and mechanistic studies
  • Scintillation assays
  • Radiometric cAMP assays
  • Detection of binding to over 80 different receptor types

Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.

For research and investigational use only.

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"Radiochemicals" 1-50 of 774 Products and Services

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Peptide YY (Human), ([125I]-PYY)

Peptide YY, labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.

ATP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide Lead, 250 µCi

Adenosine triphosphate, labeled on the alpha phosphate group with 32P

Testosterone, [1,2,6,7-3H(N)]-, 250µCi (9.25MBq)

250 µCi quantities of [1,2,6,7-3H(N)]-Testosterone are available for your research.
PerkinElmer

Streptavidin PVT 500MG

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.

Gastric Inhibitory Polypeptide (human), [125I]

Gastric inhibitor polypeptide (GIP), labeled with 125I. GIP is a hormone that binds receptors found on beta cells in the pancreas.

UTP, [α-33P]- 3000Ci/mmol, 10mCi/ml

As of August 17, 2018, we will be discontinuing all P33 nucleotides and P33 nuclides. The last day for shipping any of these products will be August 16, 2018. Uridine triphosphate, labeled on the alpha phosphate group with 33P.

dTTP, [α-32P]- 800Ci/mmol 10mCi/ml EasyTide Lead, 250 µCi

Thymidine triphosphate (deoxythymidine triphosphate), labeled on the alpha phosphate group with 32P.
PerkinElmer

Glutathione PVT 2G

Glutathione-coated SPA beads, for capturing GST-tagged proteins in proximity-based radiometric scintillation assays.

L-α-DiPalmitoyl, Phosphatidic Acid, -[glycerol-14C(U)]-, 5µCi (185kBq)

L-α-Dipalmitoylphosphatidic acid (DPPA), labeled with 14C on the glycerol group. This radiochemical is used to measure in lipid metabolism studies.

Guanosine Diphosphate Fucose, [Fucose-2-3H(N)], 50µCi (1.85MBq)

50 µCi quantities of Guanosine Diphosphate Fucose, [Fucose-2-3H(N)]- are available for your research.

Carnitine HCl, L-[Methyl-3H]

Acetyl-L-carnitine HCL is a mitochondrial metabolite that facilitates the movement of fatty acids into the mitochondria for energy and is also used to generate acetyl coenzyme A.

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.

Iodine-125 Radionuclide, Specific Activity: ~17Ci/mg, 10-5M NaOH (pH 8-11)

Iodine-125 Radionuclide 10-5M NaOH (pH 8-11) (reductant free) Shipped ambient. Sodium iodide in pH10 NaOH ~17Ci(629GBq)/mg

dATP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide Lead

Deoxyadenosine triphosphate, labeled on the alpha phosphate group with 32P.

Deoxy-D-glucose, 2-[1,2-3H(N)]

250 µCi quantities of Deoxy D Glucose are available for your research.

UTP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide

Uridine triphosphate, labeled on the alpha phosphate group with 32P.

PcP, [5`-32P]- 3000Ci/mmol 10mCi/ml Lead, 250 µCi

Cytidine 3', 5' bis(phosphate) (pCp) is labeled on the 5' phosphate group with 32P.

GTP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide Lead, 250 µCi

Guanosine triphosphate, labeled on the alpha phosphate group with 32P.

SERINE, L-[3-14C]-

50 µCi quantities of [14C(U)]-serine are available for your research.

Neurokinin B, [125I]His, MePhe7

Neurokinin B (NKB), labeled with 125I on the histidine residue. Neurokinin B is involved in ovarian cycle regulation, and binds neurokinin 3 receptor (NK3R; tachykinin receptor 3), a GPCR involved in vascular remodeling, angiogenesis, and cancer.

MK-801, (+)-[3-3H]-

(+)-MK-801 radioligand tritriated at the 3 position. MK-801 acts as a non-competitive antagonist at the glutamate receptor, N-Methyl-D-aspartate (NMDA).

Vasopressin (Linear), V-1A Antagonist (Phenylacetyl1, 0-Me-D-Tyr2, [125I-Arg6]-)

Vasopressin (linear), labeled with 125I. Linear vasopressin acts as an antagonist at vasopressin receptor 1A (V1AR).

Cholesteryl Oleate, [Oleate-1-14C]-, 250µCi (9.25MBq)

250 µCi quantities of [Oleate-1-14C]-Cholesteryl Oleate are available for your research.

Prostaglandin F2α, [5,6,8,9,11,12,14,15-3H(N)]-, 250µCi (9.25MBq)

250 µCi quantities of tritiated Prostaglandin F are available for your research. This product has a scheduled release date for the third Monday in April and October.

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).

Thymidine, [6-3H]-,>97%, 250µCi (9.25MBq)

250 µCi quantities of [6-3H]-Thymidine are available for your research

Orexin A, [125I]

Orexin A, labeled with 125I. Orexin A binds to orexin receptors (OX1 and OX2), which are potential drug targets for sleep disorders.

Cocaine, Levo-[benzoyl-3,4-3H(N)]-

Cocaine, tritiated at the benzoyl-3,4 position. Cocaine binds and blocks the dopamine transporter, preventing removal of dopamine from synapses in the brain.

Triiodothyronine, ([125I]-T3), Specific Activity: 135-165 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).

Vasopressin (8-L-Arginine), [Phenylalanyl-3,4,5-3H(N)]

Vasopressin, tritiated on the phenylalanine residue. Vasopressin binds and activates vasopressin receptors.

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). This product has a scheduled lot release for the first Monday in May and November.

dCTP, [α-32P]- 3000Ci/mmol 10mCi/ml

Deoxycytidine triphosphate, labeled on the alpha phosphate group with 32P.

dTTP, [α-32P]- 3000Ci/mmol 10mCi/ml Lead, 250 µCi

Thymidine triphosphate (deoxythymidine triphosphate), labeled on the alpha phosphate group with 32P.

Iodo-Melatonin, 2-[125I]

Melatonin, labeled with 125I. Melatonin binds and activates melatonin receptors, a class of GPCRs that are potential drug targets for circadian rhythm sleep disorders and depression.

Guanosine 5`-(γ-thio)triphosphate, [35S]-, 10mM Tricine (pH 7.6), 10mM DTT, 1.0mC/mL

Guanosine triphosphate, labeled on the gamma phosphate group with 35S (GTPγS).
PerkinElmer

Anti-rabbit PVT 500 MG

Anti-rabbit-coated SPA beads, for capturing rabbit IgG antibodies in proximity-based radiometric scintillation assays.
PerkinElmer

Streptavidin PVT 25 X 2G

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.

MALIC ACID, L-[U-14C]

50 µCi quantities of L-[U-14C]-Malic acid are available for your research.

L-[4,5-3H(N)]-Leucine, Specific Activity 40-60Ci (1.48-2.22TBq)/mmol

250 µCi quantities of tritiated L-leucine are available for your research.
PerkinElmer

WGA YSI 1G

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.

Endothelin-1 (human, porcine), [125I]Tyr13

Endothelin-1 (ET-1), labeled with 125I on the tyrosine 13 residue. Endoethlin-1 is a vasoconstrictor that acts as an endogenous agonist at endothelin receptors. Endothelin receptors are a class of GPCRs that are potential drug targets for hypertension and cancer.

Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A1 receptor.

GLUCOSE, 3-0-[METHYL-D-1-3H]

3-O-Methyl-D-Glucose is a non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.

Cytisine HCl, [3,5-3H(N)]

Cytisine HCl, [3,5-3H(N)]- will have fresh lot dates on the second Monday in April.

Iodine-125 Radionuclide, 10-5M NaOH (pH 8-11), Concentration: >350mCi/mL

Iodine-125 Radionuclide 10-5M NaOH (pH 8-11) (reductant free) Shipped ambient. Sodium iodide in pH10 NaOH ~17Ci(629GBq)/mg

L-[Methyl-3H]-Methionine

250 µCi quantities of L-[Methyl-3H]-Methionine are available for your research.

Glucose, D-[1-14C]-, 250µCi (9.25MBq)

250 µCi quantities of D-[14C(U)]-Glucose are available for your research.

dCTP, [α-32P]- 6000Ci/mmol 20mCi/ml EasyTide

Deoxycytidine triphosphate, labeled on the alpha phosphate group with 32P.

"Radiochemicals" 1-50 of 774 Products and Services

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