PerkinElmer

Lead Optimization

OF

Engineer drug candidates with the lowest risk of failure in the critical latter stages of drug development. Our lead optimization solutions reduce off-target activity through improved selectivity, enhance potency, and improve the chemical and metabolic properties of the lead compound for better in vivo pharmacodynamics and pharmacokinetics.

We also offer informatics software applications that help you manage chemical structures and their associated data and properties in an efficient and chemically intelligent way.

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Accessories (47)
  • Consumables (4)
  • Instruments (15)
  • Reagents (48)
  • Software and Informatics (7)
Application
  • Mobility Shift (36)
Automation Compatible
  • Yes (5)
Detection Method
  • Absorbance (5)
  • Alpha (4)
  • Fluorescence (7)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Label-free (1)
  • Luminescence (5)
  • Time-Resolved Fluorescence (TRF) (5)
  • Transmission (2)
Imaging Modality
  • High Content (2)
  • microCT Imaging (1)
  • Optical Imaging (6)
  • PET Imaging (1)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Product Brand Name
  • EnSight (1)
  • EnSpire (3)
  • EnVision (2)
  • G-Platform (1)
  • IVIS (6)
  • LabChip EZ Reader (49)
  • Opera Phenix (8)
  • Operetta (29)
  • Operetta CLS (1)
  • PerkinElmer Signals Lead Discovery (1)
  • Victor (1)
  • ViewLux (1)
Sample Type
  • Enzyme (38)

"Lead Optimization" 1-50 of 121 Products and Services

Sort
Per Page
VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
IVIS Spectrum In Vivo Imaging System

IVIS Spectrum In Vivo Imaging System

The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina LT In Vivo Imaging System

The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
EnSpire Alpha Plate Reader

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

EnVision 2105 multimode plate reader

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

ViewLux uHTS Microplate Imager

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

Operetta CLS HCS System

Operetta CLS High-Content Analysis System

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

IVIS Lumina XRMS In Vivo Imaging System

Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina III In Vivo Imaging System

The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
Opera Phenix HCS Systems

Opera Phenix High-Content Screening System

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
IVIS Spectrum In Vivo Imaging System

IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
G4 Preclinical PET benchtop scanner with integrated X-ray

G4 PET/X-ray Preclinical Imaging System

Ultrasensitive and fast multimodal PET/X-ray imaging at your benchtop. The G-Platform offers and includes the G4 and G8 imaging systems.
EnSpire Alpha Plate Reader

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

IVIS SpectrumCT In Vivo Imaging System

The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
EnSight Multimode Plate Reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 33, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 33 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 4, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 30, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 30 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 29, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 29 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 27, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 27 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 15, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 15 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

PDE Substrate iFL-cAMP, for LabChip EZ Reader

Fluorescently-labelled cAMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 5, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 12, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 12 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 1, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 1 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 16, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 16 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

Histone 3 Acetylated Peptide, for LabChip EZ Reader

Fluorescently-labelled Histone 3 Peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 22, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 22 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 31, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 31 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 2, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 1, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 2, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 2 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

HDAC (Histone Deacylase) Substrate A, for LabChip EZ Reader

Fluorescently-labelled Substrate A peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 24, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 24 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 34, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 34 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 32, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 32 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 6, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 6 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 3, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 8, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 14, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 14 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

LabChip Sipper Chip Coating Reagent 8 (2 ml), for EZ Reader

Coating reagent 8 (CR8) is a positively-charged additive that can be added to the separation buffer. It will bind the silanol groups of the glass channels in the LabChip multi-sipper chip (the glass is negatively-charged) to neutralize the charge.
PerkinElmer

p53 Acetylated Peptide, for LabChip EZ Reader

Fluorescently-labelled p53 Peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 7, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 11, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 11 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

Histone 4 Acetylated Peptide, for LabChip EZ Reader

Fluorescently-labelled Histone 4 Peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 26, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 26 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Peptide Substrate 10, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 10 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 9, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 25, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 25 for kinase assays (inhibiton, target discovery, lead optimization)

"Lead Optimization" 1-50 of 121 Products and Services

Per Page