PerkinElmer

Drug Discovery Screening Reagents

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Drug discovery is a complex, costly and time-consuming undertaking. For research scientists, screening potential candidates is where the journey begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our drug discovery screening reagents do just that. Whether you are doing high throughput screening or focused screening, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE® TR-FRET, DELFIA® TRF, and other assay technologies to suit you screening assay needs.

Accelerate your workflow with our drug discovery screening reagents while getting consistent, accurate and physiologically relevant results.

AlphaLISA assay principle
AlphaLISA assay principle

Alpha Technology

Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein post-translational modifications, protein:protein interactions, peptides, sugars and small molecules.

  • Ease-of-use: homogeneous, no-wash assay, with no separation steps
  • Fast: results in 3 hours for most applications
  • High sensitivity: detect down to femtogram levels of target
  • Large dynamic range: 4-5 logs
  • Compatible with many samples types: serum, plasma, cerebrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more

Choose the Alpha solution that’s right for you

  • AlphaLISA® – when running large numbers of ELISA from the same sample or working with difficult matrix, serum or plasma
  • AlphaLISA SureFire® Ultra and AlphaScreen® SureFire – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
  • AlphaPlex – for measuring more than one analyte from the same well, by using the specific wavelengths of Europium, Terbium and Samarium atoms.
  • Alpha SureFire Ultra Multiplex – for measuring two phospho-events or one phospho and a “total” protein control from the same well.
  • AlphaScreen® – perfect for studying fusion-tagged proteins or protein: protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Toolbox – when your target doesn’t have an off-the-shelf kit, the toolbox gives you everything you need to create your own. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Biomarker kits – more than 200 validated and ready to use sandwich immunoassays. Available as AlphaLISA and AlphaPlex products.
LANCE biomarker detection assay principle
LANCE biomarker detection assay principle

LANCE Ultra TR-FRET

From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.

  • No-wash/separation steps
  • Homogeneous dispense-and-read technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 384-well and 1536-well formats

LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.

DELFIA_trf
DELFIA_trf

DELFIA

DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a proven, robust immunodetection platform based on time-resolved fluorescence (TRF) detection. This detection method, coupled with the unique chemical properties of lanthanide chelates, makes DELFIA a superior alternative to conventional ELISA for research, drug discovery, and clinical applications.

DELFIA offers a combination of high sensitivity, wide dynamic range and long-lasting stability that traditional ELISA cannot match. 

Reporter gene assay
Reporter gene assay

Reporter Gene Assays

Whether your assay requires the sensitivity provided by high signal intensity, or the flexibility of an extended signal half-life, PerkinElmer provides a solution. Choose from one of three luciferase detection systems: neolite, britelite plus, or steadylite plus depending on the specific requirements of your experiment.
  • No more washing – just add your lites reagent of choice, mix, incubate, and read
  • Hassle-free storage – all lites reagents are designed for extended storage at 2-8 °C (no -20 °C storage required)
  • Odor-friendly, eliminates hood work – lites products do not contain DTT and do not have the hazards and repugnant odor typical of conventional luciferase detection systems
  • Excellent Z’ values – superior S/B ratios allow for excellent Z’ values in antagonist and agonist studies
ATPlite assay principle
ATPlite assay principle

ATP Quantitation

For fast, reliable detection of ATP for cell quantitation, ATPlite 1step and ATPlite are innovative technologies that measure cell proliferation and cytotoxicity in mammalian cells based on the detection of ATP using firefly luciferase.

ATPlite 1step – Highest sensitivity

  • True “mix and measure” continuous processing
  • Ultra high sensitivity, 3 times more light output than ATPlite
  • Short equilibrium time for faster processing
  • Signal half-life of 30 minutes

ATPlite – Convenient, extended Signal

  • 2-step format, non-separation assay for time course studies; lysate can be stored frozen and tested later
  • Quantitate from <5 cells/well
  • Prolonged equilibrium time for batch processing
  • Signal half-life of 5 hours
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AlphaLISA immunoassay kits

FCGR3A/CD16A (176Phe/F158) (human) AlphaLISA Detection Kit

This kit is designed for the detection of binding activity between human FCGR3A (176Phe) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
AlphaLISA immunoassay kits

IL-11 (human) AlphaLISA Detection Kit

The AlphaLISA® Human Interleukin 11 (IL-11) Detection Kit is designed for detection and quantitation of IL-11 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
AlphaLISA immunoassay kits

Alpha-1 Anti-Trypsin (A1AT) (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human A1AT enables the detection and quantitation of human A1AT (hA1AT) in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows negligible cross-reactivity with Human Anti-thrombin and mouse A1AT.
AlphaScreen cAMP assay principle

AlphaScreen cAMP Detection Kit

AlphaScreen no-wash assay kit for quantitative detection of cAMP.

LANCE Ultra ULight™-DNA Topoisomerase 2-alpha (Thr1342) Peptide

Generic peptide substrate for use in TR-FRET biochemical kinase assays. Refer to Selector Guide for validated kinases. Synthetic peptide containing residues surrounding Thr1342 of human DNA Topoisomerase 2-alpha; phosphorylation site: Thr1342. The ULight-DNA Topoisomerase 2-alpha (Thr1342) peptide can be phosphorylated by PLK3, CK2α and other kinases. Phosphorylation motif: DEKTDDE
AlphaLISA immunoassay kits

IFN-α (human) AlphaLISA Detection Kit

The AlphaLISA® Human Interferon-alpha (IFN-α) Detection Kit is designed for detection and quantitation of human IFN-α in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The analyte in this kit consists of the IFN-α 2b subtype.

Albumin (human) AlphaLISA Detection Kit

AlphaLISA no-wash immunoassay kit for detection of human serum albumin (HSA) in urine, buffered solution, or cell culture medium.
LANCE Detection Kit

IL-28B (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human IL-28B Detection Kit is designed for detection and quantitation of human IL-28B in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Factor VIII (human) AlphaLISA Detection Kit

The AlphaLISA® Human Factor VIII Detection Kit is designed for detection and quantitation of Human Factor VIII in human serum, plasma, and cell culture supernatants using a homogeneous (no-wash steps, no separation steps) assay.
Assay principle of Alpha Terbium SureFire Ultra assay

Total Cofilin Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two targets in each well of an assay plate. This kit can be used in combination with the AlphaLISA SureFire Ultra phospho-cofilin assay to normalize to levels of total cofilin.
AlphaLISA SureFire Ultra kits

Phospho-ZAP-70 (Tyr319) AlphaLISA SureFire Ultra Detection Kit

The AlphaLISA® SureFire® Ultra™ phospho-ZAP-70 assay is a sandwich immunoassay for quantitative detection of ZAP-70 (phosphorylated on Tyr319) in cellular lysates using Alpha Technology.

Anti-Mouse IgG2a (isotyping) AlphaLISA Acceptor beads

AlphaLISA® Acceptor beads conjugated to a anti-mouse IgG2a. This bead can be used to create no-wash AlphaLISA assays for isotyping and other applications.
AlphaLISA immunoassay kits

IP-10 (human) AlphaLISA Detection Kit

The AlphaLISA® Human Interferon Gamma-induced Protein 10 (hIP10) Detection Kit is designed for the quantitative determination of human IP10 in serum, plasma, and cell culture supernatants using a homogeneous (no wash steps, no separation steps) assay.
AlphaLisa Analyte 2

E-Cadherin (human), lyophilized (AlphaLISA)

Human E-cadherin standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human E-cadherin Detection Kit, but can be ordered separately.

LANCE Ultra ULight™-Acetyl-CoA Carboxylase (Ser79) Peptide

Generic peptide substrate for use in TR-FRET biochemical kinase assays. Refer to Selector Guide for validated kinases. ULight-labeled synthetic peptide derived from residues 73-85 of rat Acetyl-CoA Carboxylase in which Ser77 is mutated to Ala (also known as SAMS). The ULight-Acetyl-CoA Carboxylase peptide can be phosphorylated at Ser 79 by the AMPKα1 kinase. Peptide sequence : CHMRSAMSGLHLVKRR. Please note this product replaces TRF0118-D or TRF0118-M, now being supplied lyophilized rather than in liquid (frozen) format.
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA Sm-N1 Streptavidin

Samarium-labeled streptavidin for binding biotinylated biomolecules in DELFIA® time-resolved fluorescence (TRF) assays.

CCL5/RANTES (human) AlphaLISA Detection Kit

The AlphaLISA® Human C-C Motif Chemokine 5 / Regulated Upon Activation Normal T-cell Expressed and Secreted (CCL5 / RANTES) Detection Kit is designed for detection and quantitation of human CCL5/RANTES in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
AlphaLisa Analyte 2

Kappa light chain (human), lyophilized (AlphaLISA)

Human kappa light chain standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human Kappa Light Chain Detection Kit, but can also be ordered separately.

Insulin (human) AlphaLISA Detection Kit

The AlphaLISA® Human Insulin Detection Kit is designed for detection and quantitation of human insulin in cell culture supernatants, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.
Protein

IL-1RA (human), lyophilized (LANCE)

Human IL-1RA standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human IL-1RA Detection Kit, but can also be ordered separately.

Hepatitis B Virus e Antigen (HBeAg) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for hepatitis B virus (e antigen; HBeAg) enables the quantitative determination of HBeAg in cell culture media using a homogeneous AlphaLISA assay (no wash steps).
AlphaLisa Analyte 2

Factor VIII, human, 0.3 µg, lyophilized (AlphaLISA)

Human Factor VIII standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human Factor VIII Detection Kit, but can be ordered separately.
AlphaLISA immunoassay kits

IL-12 (porcine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for porcine IL-12 enables the quantitative determination of porcine interleukin-12 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-STAT3 (Tyr705) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-STAT3 (Tyr705) in a multiplexed assay.

Amyloid β 1-42 (mouse/rat) AlphaLISA Detection Kit

The AlphaLISA® Mouse/Rat Amyloid beta (Aß 1-42) Detection Kit is designed for detection and quantitation of mouse or rat Aß 1-42 in serum, cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
AlphaLISA SureFire Ultra kits

Phospho-VEGFR2 (Tyr1214) AlphaLISA SureFire Ultra Detection Kit

The AlphaLISA® SureFire® Ultra™ phospho-VEGFR2 assay is a sandwich immunoassay for quantitative detection of VEGFR (phosphorylated on Tyr1214) in cellular lysates using Alpha Technology.
PerkinElmer

LANCE Ultra STAT5 Positive Control Lysate

Control lysates for LANCE Ultra TR-FRET cellular phospho-STAT5 detection assays.
AlphaLISA immunoassay kits

IgM (human) AlphaLISA Detection Kit

The AlphaLISA® Human IgM Protein Detection Kit is designed for detection and quantitation of human IgM in serum, buffered solution or cell culture medium using a homogeneous (no wash steps, no separation steps) assay.

Anti-bovine IgG AlphaLISA Acceptor Beads

AlphaLISA Acceptor beads conjugated to anti-bovine IgG (total) antibody.
AlphaLISA immunoassay kits

IL-8 (human) AlphaLISA Biotin-Free Detection Kit

The AlphaLISA Human IL8 Biotin-Free Detection Kit is designed for the quantitative detection of human IL-8 in serum, cell culture medium, and other samples types using a homogeneous (no wash steps, no separation steps) assay. The biotin-free kit uses anti-DIG (anti-Digoxin) Donor beads instead of streptavidin Donor beads, which makes the kit compatible with high-biotin culture media and other sample types that contain high levels biotin (including brain/liver tissue extracts, milk and eggs).
AlphaLISA immunoassay kits

FcγR2A/CD32a (167H) AlphaLISA Binding Kit

This kit is designed for the detection of binding between FCGR2A (CD32a) (167H) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics by using competitive binding.
AlphaLISA immunoassay kits

Vimentin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human vimentin enables the quantitative determination of human vimentin in serum, buffered solution, and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
alphascreen surefire total

AlphaScreen SureFire Total Akt1 research kit

The AlphaScreen® SureFire® Akt 1 (total) assay is a sandwich immunoassay for quantitative detection of Akt 1 in cellular lysates using Alpha Technology. The assay is an ideal system for normalizing Akt levels for experiments measuring changes in Akt phosphorylation. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
PerkinElmer

LANCE Ultra LCK Positive Control Lysate

Control lysates for LANCE Ultra TR-FRET cellular phospho-LCK detection assays.
Alpha donor antibody coated

Anti-DNP Alpha Donor Beads

Alpha Donor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
SureFire principle

AlphaScreen SureFire Histone H3 (p-Ser10) Assay Kit

The AlphaScreen® SureFire® p-Histone H3 (Ser10) assay is a sandwich immunoassay for quantitative detection of phospho-Histone H3 (phosphorylated on Ser10) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.

DELFIA Eu-DTPA-DTA Chelate and Europium (Eu) Standard, 1mg

Europium labeling chelate for creating your own Europium-labeled biomolecules for use in DELFIA time-resolved fluorescence (TRF) assays. The DTA-activated chelate reacts with free amino groups, sulfhydryl groups, and hydroxyl groups. Because of its high reactivity, we usually do not recommend DTA as it may “inactivate” the reagent you are labeling. The DTPA chelate is more-stable than the N1 chelate.

LANCE Ultra cAMP Detection Kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
AlphaLISA immunoassay kits

Kappa light chain (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human kappa light chain enables the quantitative determination of human kappa light chain in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
PerkinElmer

LANCE Ultra m/rIL17A, lyophilized(1.0ug)

LANCE Ultra m/rIL17A, lyophilized(1.0ug)

FcγR3B (CD16b) AlphaLISA Binding Kit

The AlphaLISA FCGR3B (CD16b) binding kit is designed for the detection of binding between FcγR3B (CD16b) and human IgG Fc fragment using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics using a competition assay format.
Protein

ErbB2 (human), lyophilized (LANCE)

Human ErbB2 (HER2) standard, lyophilized, for use in running standard curves in LANCE TR-FRET no-wash detection assays. This standard is already provided in the LANCE Ultra Human ErbB2 TR-FRET Detection Kit, but can be ordered separately.
AlphaLISA immunoassay kits

TNFR1 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human tumor necrosis factor receptor 1 (TNFR1) enables the quantitative determination of human TNFR1 in buffered solution, serum, lysates, and cell culture media using a homogeneous AlphaLISA assay (no wash steps).

EGFR (human) AlphaLISA Detection Kit

The AlphaLISA® EGFR Detection Kit is designed for detection and quantitation of human Epidermal Growth Factor Receptor (EGFR) in cell culture media, human serum, and other sample types using a homogeneous (no-wash steps, no separation steps) assay.

Albumin (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human Albumin Detection Kit is designed for detection and quantitation of human albumin in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Anti-methyl-Histone H3 Lysine 4 (H3K4me1-2) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 mono- or di-methylated at lysine 4 (H3K4me1-2). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
AlphaPlex Terbium immunoassay kits

AlphaPlex™ 545 Human Insulin Detection Kit

The AlphaPlex™ 545 (Terbium) Human Insulin Detection Kit is designed for the quantitative determination of human Insulin together with another analyte (AlphaLISA) in serum, buffered solution or cell culture medium using a homogeneous assay.
AlphaLISA immunoassay kits

IL-18 (bovine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for bovine IL-18 enables the quantitative determination of bovine interleukin 18 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
AlphaLISA immunoassay kits

MCP2 (mouse) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for mouse MCP2 enables the quantitative determination of mouse monocyte chemoattractant protein 2 (MCP2; CCL8) in buffer and serum using a homogeneous AlphaLISA assay (no wash steps).
AlphaLisa Analyte 2

IL-6 (human), lyophilized (AlphaLISA)

Human Interleukin-6 (IL6) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA human IL-6 kit, but can be ordered separately.

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