PerkinElmer

GPCR

OF

G-protein-coupled receptors (GPCR) are the largest and most widely-varying group of membrane receptors, including beta 1 and beta 2 adrenergic, dopaminergic, and cholinergic receptors. From start to finish, we offer state-of-the-art equipment for GPCR research.

We provide GPCR assay reagents for any target, including Gs-, Gq- and Gi-coupled receptors. Our full line of products includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based GPCR assay platforms
  • Versatile reagents—GPCR cell lines, frozen and ready-to-use cells, ligands and radioligands, and cloned receptor membranes

This extensive product portfolio covers all your bases for research with G-protein-coupled receptors. Count on these tools for identifying and monitoring a variety of GPCR research applications, including:

  • GPCR pathway activation via intracellular calcium, cAMP, phospho-ERK, inositol phosphates
  • Reporter gene expression in response to GPCR signaling
  • Receptor-ligand binding
  • GTPgammaS binding activity

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Product Type
  • Accessories (3)
  • Instruments (4)
  • Reagents (92)
Assay Target
  • Akt1 (2)
  • Akt1/2 (1)
  • Akt1/2/3 (4)
  • cAMP (3)
  • CREB (2)
  • ERK1/2 (4)
Target Species
  • Human (11)
Application
  • cAMP (8)
  • Drug Discovery & Development (41)
  • Kinase (6)
  • Multiplexing (2)
  • Protein Analysis & Detection (6)
Therapeutic Area
  • Angiogenesis (1)
  • Cardiovascular (29)
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  • Diabetes (7)
  • Gastrointestinal (14)
  • Inflammation (32)
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  • Obesity (2)
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Product Brand Name
  • AequoScreen (9)
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  • Alpha SureFire Ultra Multiplex (2)
  • AlphaLISA SureFire Ultra (3)
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  • NEN Radiochemicals (3)
  • NEN Radiolabeled Ligands (7)
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Detection Method
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  • Luminescence (4)
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  • Time-Resolved Fluorescence (TRF) (6)
  • TR-FRET (2)
Molecular Modification
  • Phosphorylation (8)
Receptor Type
  • 5-Hydroxytryptamine (2)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
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  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Assay Validated
  • Binding (39)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (25)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Radioisotope
  • C-14 (2)
  • H-3 (2)
  • I-125 (7)
Radionuclide
  • 125I (7)
  • 3H (2)
Label Position
  • Nominally Labeled (7)
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Assay points(200-50,000)
  • 100 (2)
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  • 50000 (11)
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  • GPCR (55)
  • Phosphoprotein (12)
  • Protein (3)
Automation Compatible
  • Yes (26)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (1)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Experimental Type
  • In vitro (12)
Format
  • Microplates (15)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (33)
  • HEK293 (26)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Pipetting Arms

"GPCR" 1-50 of 99 Products & Services

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VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
ViewLux uHTS Microplate Imager

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

EnSight Multimode Plate Reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
EnVision 2105 multimode plate reader

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1b receptor, in HEK-293 cells.
List Price : 7820.00 SEK
Receptor-expressing cell lines

AequoZen Frozen cells, Adenosine α2A, Human Recombinant, HEK293

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 8110.00 SEK
PerkinElmer

Membrane Target Systems: GABA B1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1a receptor, 400 units.
List Price : 7820.00 SEK
PerkinElmer

Membrane Target Systems: Neurokinin NK1 (human endogenous) membrane preparation, in UC11 cells. 400 Units.

Cell membranes prepared from UC11 cells with human neurokinin NK1 receptor, 400 units.
List Price : 7820.00 SEK
PerkinElmer

Membrane Target Systems: Serotonin 5HT1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from cells stably-transfected with human serotonin 5HT1a receptor
List Price : 7820.00 SEK
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
List Price : 8200.00 SEK
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 7820.00 SEK
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, 1321N1 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 8110.00 SEK
Alpha Bungarotoxin

Motilin, [125I]

Motilin, labeled with 125I. Motilin is a peptide hormone that binds motilin receptors, and stimulates contraction of gut smooth muscle.
Price Range : 9730.00 SEK - 19600.00 SEK
alphascreen surefire total

Total ERK (monoclonal) AlphaScreen SureFire Assay Kit

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 16500.00 SEK - 176100.00 SEK
Diclofenac sodium- Phenylacetic acid C14

Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[1-14C]

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.
Price Range : 6440.00 SEK - 27600.00 SEK
Receptor-expressing cell lines

Adenosine A3 AequoScreen® cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Adenosine 5 Triphosphate 250 µCi

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 5240.00 SEK - 40900.00 SEK
Alpha Bungarotoxin

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.
Price Range : 4910.00 SEK - 13400.00 SEK
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 16500.00 SEK - 176100.00 SEK
Receptor-expressing cell lines

AequoZen FroZen cells, Adenosine A1, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 8110.00 SEK
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 16500.00 SEK - 176100.00 SEK
Receptor-expressing cell lines

AequoScreen Cells, opioid delta receptor, human recombinant, HEK293

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
SureFire principle

AlphaScreen SureFire CREB (p-Ser133) Assay Kit

The AlphaScreen® SureFire® p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 16500.00 SEK - 176100.00 SEK
Receptor-expressing cell lines

AequoScreen Cells, opioid kappa receptor, human recombinant, HEK293

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Alpha Bungarotoxin

CGRP (human), [125I]

Calcitonin gene-related peptide (CGRP), labeled with 125I. CGRP binds calcitonin receptors.
Price Range : 6730.00 SEK - 16300.00 SEK
PerkinElmer

Membrane Target Systems: Opioid Kappa (OP2) (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human opioid kappa (OP2) receptor, 400 units.
List Price : 7820.00 SEK
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit

The AlphaLISA® SureFire® Ultra p-AKT1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-AKT1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 4870.00 SEK - 282500.00 SEK
PerkinElmer

Membrane Target Systems: Melatonin MT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes expressing recombinant human melatonin MT1 receptor, for ligand binding assays. Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
SureFire principle

Phospho-ERK (Thr202/Tyr204) Monoclonal AlphaScreen SureFire Assay kit

The AlphaScreen® SureFire® p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 16500.00 SEK - 176100.00 SEK
Alpha Bungarotoxin

GLP-1 (7-36), [125I]

Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
Price Range : 10300.00 SEK - 18800.00 SEK
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 7610.00 SEK
PerkinElmer

Membrane Target Systems: Adenosine A1 (rat) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with rat adenosine A1 receptor, 400 units.
List Price : 7820.00 SEK
PerkinElmer

Membrane Target Systems: Vasopressin V1a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1a receptor, in HEK-293 cells.
List Price : 7820.00 SEK
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, 1321N1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 8110.00 SEK
Alpha Bungarotoxin

Insulin (human, recombinant), [125I]

[125I]-Insulin (h) is suitable for the use in radioimmunoassay as well as receptor binding assay. [125I]-Insulin (h) is radioiodinated with no carrier added 125I using the LPO iodination procedure and is purified by reversed phase HPLC.
Price Range : 9150.00 SEK - 17800.00 SEK
Receptor-expressing cell lines

AequoZen FroZen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 8110.00 SEK
PerkinElmer

LANCE cAMP Detection Kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 1410.00 SEK - 62900.00 SEK
PerkinElmer

Membrane Target Systems: Serotonin 5HT2c (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human serotonin 5HT2c receptor, 400 units.
List Price : 7820.00 SEK
Receptor-expressing cell lines

Adenosine A1 AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Melatonin MT2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes expressing recombinant human melatonin MT2 receptor, for ligand binding assays. Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
PerkinElmer

Membrane Target Systems: Thromboxane TP (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Thromboxane TP receptor, in HEK-293 cells.
List Price : 7820.00 SEK
Receptor-expressing cell lines

ValiScreen Cells, opioid delta receptor, human recombinant, CHO-K1

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

Adrenergic alpha 2B AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

LANCE Ultra cAMP Detection Kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
Price Range : 5370.00 SEK - 69800.00 SEK
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gαq/i5)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 8110.00 SEK
PerkinElmer

Membrane Target Systems: U-373 cell membranes

Wild Type Subtype U-373 (human) Control Membrane Frozen suspension cell membrane. Shipped on dry ice.
List Price : 4660.00 SEK
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 7430.00 SEK - 431600.00 SEK
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
Price Range : 4870.00 SEK - 282500.00 SEK
SureFire principle

AlphaScreen SureFire Phospho-AKT (Thr308) Kit

The AlphaScreen® SureFire® p-Akt1 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Thr308) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 14900.00 SEK - 160700.00 SEK
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Vasopressin V1b receptor, 400 units.
List Price : 7820.00 SEK

"GPCR" 1-50 of 99 Products & Services