Visualize and quantify uptake of monoclonal antibodies (mAbs) using Zirconium-89 (89Zr). With a long-lived half-life of (3.3 days), 89Zr is well suited as a PET Imaging biomarker to access target expression as well as tumor targeting of mAbs.
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Zirconium-89 radionuclide, dispensed for Monday* calibration. 89Zr is particularly suitable for PET imaging of internalizing mAbs. This calibration date is currently only available outside North America. 89Zr-immuno-PET can offer excellent sensitivity and accurate quantification of mAbs or mAb-fragments in pre-clinical in vivo models. 89Zr's physical half-life of 78.4 hr matches the biological half-life of a mAb, as well as the time it needs to perfectly reach optimal target-to-non-target ratios. Literature suggests that PET image quality is not disturbed by the decay of this residualizing isotope.
*Monday calibration date available only outside North America.
|Product Brand Name||NEN Radiochemicals|
|Quantity in a Package Amount||1.0 per pack|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
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|Poster||Multimodality workflow for assessing drug distribution & efficacy in breast cancer xenografts||PDF 908 KB|
|Event||Society of Nuclear Medicine and Molecular Imaging (SNMMI)|
|Webinars||Novel PET radiochemistries: Improving understanding & detection of disease - View On Demand||Link|
|Webinars||Accelerating Therapeutic Development Through PET and Optical Preclinical Imaging - View On Demand||Link|