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Staphylococcus aureus - Xen8.1

Staphylococcus aureus - Xen8.1 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain 8325-4. Staph. aureus-Xen8.1 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

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Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVISĀ® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

  • Engineered Bacterium: Staphylococcus aureus - Xen8.1
  • Parental Strain: 8325-4
  • In Vitro/Ex Vivo: Growth profiles, Catheter model
  • In Vivo: Sepsis, Soft tissue, Pouch, Pneumonia, Biofilm models

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

  • Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
  • Sensitivity - subtle changes in cellular viability are rapidly detected
  • Inexpensive - no additional substrates needed for bacterial assays

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:

  • Rapid identification of lead drug candidates
  • Real-time efficacy data
  • May help to decrease drug failure by allowing disease relapse to be monitored in the same animal

Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.

Gram Positive Gram Negative Gram positive
Luciferase Classification Bacterial luciferase
Optical Imaging Classification Bioluminescence Imaging
Product Brand Name XenoLight
Shipping Condition Ambient
Therapeutic Area Bacterial infection
Unit Size 1 agar plate

Resource Library & Events

Resource Type File Name File Format
Brochure In Vivo Imaging Agents Brochure PDF 2 MB
Technical Note Bacterial Growth Preparation PDF 26 KB
Citations Library View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents Link