PerkinElmer
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VivoTag-S 680 Fluorochrome (1mg)

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.

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For laboratory use only. This product is intended for animal research only and not for use in humans.

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Detail Information

Vivotag-S® Fluorochrome in 1 mg quantity size.  VivoTag-S fluorochrome is an amine-reactive near-infra-red fluorochrome for coupling via an NHS ester linkage to peptides, small molecules, proteins, antibodies or macromolecules.

Specifications

Fluorescent Agent Type Labeling
Optical Imaging Classification Fluorescence Imaging
Product Brand Name VivoTag
Shipping Condition Blue Ice
Unit Size 1 mg
Wave Length 680 nm
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Application Note

VivoTag S Agents (Protocol)

N-Hydroxysuccinimide (NHS)-ester labeling reagents, such as VivoTag®-S reagents, are commonly used for labeling proteins. The NHS ester moiety reacts with amino groups at pH 7-9 to form stable amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation.,Protein labeling efficiency may vary depending upon the type of protein labeled, so different conjugation ratios may need to be attempted to attain success. For Near Infrared (NIR) fluorophore conjugation, ratios of fluorophore to protein of 4:1 have been seen to generate effective imaging agents. Not all antibodies or proteins (independent of target specificity) make good imaging agents, due to long half-lives and/or excessive accumulation in non-target sites.

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Poster

Near-Infrared Quantitative Fluorescence Imaging of Renin Activity in Kidney Tissue

We have developed a novel FAST (“Fluorescent Activatable Sensor Technology”) in vivo imaging agent based on an angiotensinogen substrate sequences that is selectively cleaved and activated by rodent renin. ReninSense680 FAST, a PKM-modified agent suitable for invivo administration, distributes to the kidney, is activated in a model of renin upregulation, and provides a tool for in vivo imaging and quantification of the changes in renin activity inkidneys and plasma.

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Technical Note

VivoTag-S® 680 (1 mg) (Data Sheet)

VivoTag-S® 680 is an amine reactive near-infrared (NIR) fluorochrome (NHS ester) for labeling biomolecules for in vivo imaging applications.

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