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Vectra 3.0 Automated Quantitative Pathology Imaging System, 6 Slide

The Vectra® 3 automated quantitative pathology imaging system accurately detects and measures weakly expressing and overlapping biomarkers within a single H&E, IHC or IF intact FFPE tissue section or TMA.

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Product Number
CLS142568

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Overview

The Vectra® 3 automated quantitative pathology imaging system is available as a 6-slide or 200-slide configuration. Both accurately detect and measure weakly expressing and overlapping biomarkers within a single H&E, IHC or IF intact FFPE tissue section or TMA. Vectra and inForm® software analysis combine the power of multiplexed biomarker imaging and quantitative analysis within a familiar digital pathology workflow to accelerate your cancer immunology research.

Tissue sections or TMAs can be labeled with immunofluorescent (IF) or immunohistochemical (IHC) stains, or with conventional stains such as H&E and trichrome. When using IF or IHC stains, multiple proteins can be measured on a per tissue, per cell, or per cell compartment (e.g. nuclear, cytoplasmic) basis - even when signals are spectrally similar, are located in the same cellular compartment or are obscured by autofluorescence.

Vectra 3 introduces the Phenochart™ whole slide contextural viewer with annotation capability into the digital workflow, where pathologists and technicians can navigate around slides and identify areas of interest for high-resolution multispectral acquisition. The system features automated slide handling, multispectral imaging technology, and unique pattern-recognition-based image analysis enabling quantitative data acquisition for up to 200 slides within a single batch run. It accurately measures protein and biomarker expression and morphometric characteristics in intact tissue sections for translational studies.

Key Benefits:

  • Supports PerkinElmer’s Phenoptics™ workflow solution for cancer immunology research
  • Detects and measures multiple weakly expressed and overlapping biomarkers within a single H&E, IHC or IF tissue section and in TMAs
  • Visualizes, analyzes, quantifies and phenotypes immune cells in situ in solid tissues
  • Phenochart whole slide viewer for slide navigation provides context for identification of regions of interest within a digital pathology workflow
  • Automatic identification of specific tissue types using integrated inForm analysis software

 

Disclaimer: For research use only. Not for use in diagnostic procedures.

Resources, Events & More

All (18)
Resource Type File Name File Format
Brochure Phenoptics™ Research Solutions PDF 11 MB
Product Note Quantitative Pathology Imaging and Analysis PDF 2 MB
Product Note Vectra 3: Quickening the Pace of Understanding PDF 6 MB
E-book Download Phenoptics Research Solutions E-book Link
Poster Evaluation Of Tumor Immune Infiltrate as a Determinant of Response to Neo-Adjuvant Lapatinib Link
Scientific Paper NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Link
Scientific Paper Esbona, Karla, et al. "COX-2 modulates mammary tumor progression in response to collagen density." Breast Cancer Research 18.1 (2016) Link
Scientific Paper Feng, Zipei, et al. "Multispectral Imaging of T and B Cells in Murine Spleen and Tumor." The Journal of Immunology 196.9 (2016): 3943-3950 Link
Scientific Paper Woods, Katherine, et al. "Mismatch in epitope specificities between IFN? inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma." Journal for immunotherapy of cancer 4.1 (2016) Link
Scientific Paper Ören, Bilge, et al. "Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis." The Journal of Pathology (2016) Link
Scientific Paper Huang, Fangjin, et al. "Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET." The Journal of Pathology: Clinical Research (2016) Link
Scientific Paper Linch, Stefanie N., et al. "Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice." Proceedings of the National Academy of Sciences 113.3 (2016): E319-E327 Link
Scientific Paper NEJM: PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma Link
Scientific Paper Novartis Genoptix Shows Multiplexed IHC Test Better Predicts Immunotherapy Response Link
Scientific Paper Nghiem, Paul T., et al. "PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma." New England Journal of Medicine (2016) Link
Software Downloads Click here to download latest software Link
Webinar Using multiplexed IHC to Effectively Navigate the Hidden Clues of the Immunological Microenvironment Link
Webinar Untangling the tumor microenvironment: Illuminating the complex interactions and functions of immune cells Link