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TRIIODOTHYRONINE, L-3, 5, 3'-[125I], 500µCi (18.5MBq), Specific Activity: 3300µCi (122MBq)/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).

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Part Number
Unit Size
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NEX110X100UC
100 µCi
744.00 USD
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NEX110X250UC
250 µCi
1589.00 USD
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NEX110X500UC
500 µCi
2513.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX110:

  1. McIver, C.R., Shaw, IC., Gin, S., Ellis, M.J. (2013), Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?, Clinical Biochemistry, Volume 46, Issues 13–14, Pages 1302-1304.
  2. Mantzos, J.D., Yialouris, P.P. (1982), A simple and reproducible method for the estimation of triiodothyronine uptake (thyroxine binding index) using a new adsorbent, Clinical Biochemistry, Volume 15, Issue 2, Pages 76-79.

References for NEX110H:

  1. McConway, M.G., Chapman, R.S. (1986) Application of solid-phase antibodies to radioimmunoassay Evaluation of two polymeric microparticles, Dynospheres and nylon, activated by carbonyldiimidazole or tresyl chloride, Journal of Immunological Methods, Volume 95, Issue 2, Pages 259-266.
  2. Selliti, D.F., Latham, K.R. (1983) Multiple affinity classes of saturable triiodothyronine binding in mouse liver nuclear extract demonstrated using high-performance size exclusion chromatography, Journal of Chromatography A, Volume 268, Pages 300-305.

References for NEX110X:

  1. Glynn, N., Kenny, H., Quisenberry, L., Halsall, D. J., Cook, P., Kyaw Tun, T., McDermott, J. H., Smith, D., Thompson, C. J., O'Gorman, D. J., Boelen, A., Lado-Abeal, J. and Agha, A. (2017), The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies. Clin Endocrinol, 86: 747–754.

Specifications

Concentration 353 µCi/mL
Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Specifically Labeled
Molecular Weight 649.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Metabolic Disorders
Unit Size 500 µCi