Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism. PerkinElmer’s Transferrin-Vivo 750 fluorescent probe is a NIR-labeled in vivo imaging agent that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. Transferrin-Vivo 750 fluorescent agent can also detect normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.
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|Fluorescent Agent Type||Targeted|
|Product Brand Name||Transferrin-Vivo|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.