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TAURINE, [2,2,3H]

Taurine, tritiated at the 2,2 position. Taurine acts as an agonist at glycine receptors.

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NET1205250UC
250 µCi
1182.00 USD
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NET1205001MC
1 mCi
3805.00 USD
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Detail Information

Taurine acts as an agonist at glycine receptors. These receptors are ligand-gated ion channels, and are potential drug targets for hyperekplexia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1205:

  1. Kim C. et al. (1998) Uptake of Taurine and Taurine Chloramine in Murine Macrophages and their Distribution in Mice with Experimental Inflammation. In: Schaffer S., Lombardini J.B., Huxtable R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA.
  2. Uchida, S., Kwon, H.M., Yamauchi, A., Preston, A.S., Marumo, F., Handler, J.S. (1992) Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity, PNAS, 89 (17): 8230-8234.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 125.2
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Glycine
Shipping Condition Blue Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi