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SR 95531, [Butyryl-2,3-3H]-, 250µCi (9.25MBq)

SR-95531 (Gabazine), tritiated at the butyryl-2,3 position. SR-95531 acts as an antagonist at GABAA receptors.

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NET946250UC
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Detail Information

SR-95531 acts as an antagonist at GABAA receptors. These receptors are ligand-gated ion channels and are the target for many psychoactive drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET946:

  1. Yanlin Lei, Irene Yaroslavsky, Shanaz M. Tejani-Butt, Strain differences in the distribution of N-methyl-d-aspartate and gamma (γ)–aminobutyric acid-A receptors in rat brain, Life Sciences, Volume 85, Issues 23–26, 2009, Pages 794-799.
  2. Jon E. Hawkinson, Manuel Acosta-Burruel, Catherine L. Kimbrough, Dayan B. Goodnough, Paul L. Wood, Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site, European Journal of Pharmacology, Volume 304, Issues 1–3, 1996, Pages 141-146.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 287.3
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Benzodiazepine, GABAA
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi