Serotonin 5-HT6 AequoScreen; cell line

Overview

AequoScreen® Double Transfected Cell Lines: Serotonin, 5-HT6 subtype. Human Recombinant, in CHO-K1 host cell. Two vials of cryopreserved cells are shipped per order. A detailed technical dossier includes sequence, culture conditions and pharmacological properties of the recombinant receptor. All cell lines are tested for the absence of mycoplasma. Terms and conditions apply. Some products are not available in some countries. Please inquire at your local sales office for more information.

Features:

• Fully automatable and miniaturizable to 1536
• Enables reduction in reagents and consumable costs
• High signal to background ratio enabling detection of agonists, antagonists and allosteric modulators
• Robust assay (Z', CV values, solvent resistance)
• Reduces the number of false positives from autofluorescent compounds in screening libraries
• Option to work with cells in suspension to increase throughput
• Amenable for use with calcium coupled ion channels and tyrosine kinase receptors

The AequoScreen technology is a generic GPCR technology which can be used with Gs, Gi and Gq coupled GPCRs and calcium coupled ion channels. Following receptor stimulation, increases in intracellular calcium enable measurement of the resulting flash luminescence signal.