Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
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ReninSense 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with a broader range of early imaging timepoints. This architecture also offers higher target specific signal with reduced background.
ReninSense 680 FAST is a Renin activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by renin produced in the kidneys. The Renin-Angiotensin System (RAS) is the hormone system involved in regulating blood pressure and fluid balance in the body.
ReninSense 680 FAST is recognized and activated by rodent forms of renin in preclinical animal models. ReninSense 680 FAST may be used to monitor abnormal RAS function, progression of disease and the efficacy of therapeutic treatment in disorders such as hypertension and cardiovascular disease and some neurological diseases.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Activatable|
|One Unit Contains||10 doses|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||ReninSense|
|Shipping Condition||Blue Ice|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
|Resource Type||File Name||File Format|
|Brochure||FMT Fluorescence Tomography in vivo Imaging Systems||PDF 1 MB|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Technical Note||ReninSense 680 FAST (Protocol)||PDF 257 KB|
|Technical Note||ReninSense 680 FAST™ (Data Sheet)||PDF 189 KB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|