L-propranolol, tritiated at the 4 position. Propranolol is a non-selective beta blocker that acts as a potent antagonist for β-adrenoceptors.
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Propranolol is a beta blocker used to treat high blood pressure and irregular heart rate that acts as an antagonist at β1- and β2-adrenergic receptors. These receptors are involved in cardiac output and smooth muscle relaxation.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET515:
|Concentration||1.0 - 10 mCi/mL|
|Label Position||Nominally Labeled|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Dry Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||Cardiovascular, Inflammation, Diabetes, Metabolic Disorders, Gastrointestinal|
|Unit Size||250 µCi|