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17α-HYDROXYPROGESTERONE, [1,2,6,7-3H]

17α-Hydroxyprogesterone (17α-OHP), tritiated at the 1,2,6,7 position. 17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR), an antagonist of the mineralocorticoid receptor (MR), and a partial agonist of the glucocorticoid receptor.

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NET1195250UC
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Detail Information

17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR), an antagonist of the mineralocorticoid receptor (MR), and a partial agonist of the glucocorticoid receptor.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1195:

  1. Owen, C P., Patel, C H., Dhanani, S, Ahmed, S. Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α). Letters in Drug Design & Discovery, Volume 3, Number 10, December 2006, pp. 761-765.
  2. Tore, H., Johansson, E. Peripheral plasma levels of 17α-hydroxyprogesterone, progesterone and oestradiol during normal menstrual cycles in women. Acta Endocrinol December 1, 1972 71 743-754.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 330.46
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Progestin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Metabolic Disorders
Unit Size 250 µCi