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Peptide YY, (Porcine), ([125I]-PYY), 50µCi

Peptide YY (peptide tyrosine tyrosine), labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.

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NEX240010UC
10 µCi
1007.00 USD
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NEX240050UC
50 µCi
2326.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX240:

  1. Kuhre, R.E., Wewer Albrechtsen, N.J., Deacon, C.F., Balk-Møller, E., Rehfeld, J.F., Reimann, F., Gribble, F.M., Holst, J.J. (2016), Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol, 56 (3): 201-211.
  2. Toräng, S., Veedfald, S., Rosenkilde, M.M., Hartmann, B., Holst, J.J. (2015), The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo. Physiol Rep, 3 (7): e12455.

Specifications

Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Nominally Labeled
Molecular Weight 4365.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Neuropeptide Y
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders, Gastrointestinal
Unit Size 50 µCi