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Peptide YY (Human), ([125I]-PYY), 50µCi

Peptide YY, labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.

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Unit Size
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NEX341010UC
10 µCi
892.00 USD
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NEX341050UC
50 µCi
1999.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX341:

  1. Nishizawa, N., Niida, A., Adachi, Y., Kanematsu-Yamaki, Y., Masuda, Y., Kumano, S., Yokoyama, K., Noguchi, Y., Asakawa, T., Hirabayashi, H., Amano, N., Takekawa, S., Ohtaki, T., Asami, T. (2017), Highly potent antiobesity effect of a short-length peptide YY analog in mice. Bioorg Med Chem, 25 (20): 5718-5725.
  2. Toräng, S., Bojsen-Møller, K.N., Svane, M.S., Hartmann, B., Rosenkilde, M.M., Madsbad, S., Holst, J.J. (2016), In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans. Am J Physiol Regul Integr Comp Physiol, 310 (9): R866-874.

Specifications

Detection Method Radiometric
Fresh Lot Days First Monday of each month
Label Position Nominally Labeled
Molecular Weight 4432.17
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Neuropeptide Y
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders, Gastrointestinal
Unit Size 50 µCi