PerkinElmer
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Oxytocin, [Tyrosyl-3,5-3H]-, 50µCi (1.85MBq)

Oxytocin, tritiated on the tyrosyl group. Oxytocin is a neurotransmitter that binds and activates oxytocin receptors.

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NET858050UC
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Detail Information

Oxytocin is the endogenous ligand for oxytocin receptors. These receptors are a family of GPCRs that are involved in uterine contractions, milk production, stress, anxiety, social memory and recognition, and bonding.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET858:

  1. Braida, D., Donzelli, A., Martucci, R. et al. Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish. Psychopharmacology (2012) 220: 319.
  2. Gimpl, G., Fahrenholz, F. Cholesterol as stabilizer of the oxytocin receptor, In Biochimica et Biophysica Acta (BBA) - Biomembranes (2002) 1564 (2): 384-392.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 1007.23
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Oxytocin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Metabolic Disorders, Gastrointestinal
Unit Size 50 µCi