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Orexin A, [125I]-, 10µCi (370kBq)

Orexin A, labeled with 125I. Orexin A binds to orexin receptors (OX1 and OX2), which are potential drug targets for sleep disorders.

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Part Number Unit Size List Price Your Price Quantity
NEX367010UC 10 µCi 926.00 USD
NEX367050UC 50 µCi 1987.00 USD
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Overview

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX367:

  1. Wieland, H. A., Söll, R. M., Doods, H. N., Stenkamp, D., Hurnaus, R., Lämmle, B. and Beck-Sickinger, A. G. (2002), The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. European Journal of Biochemistry, 269: 1128–1135.

Specifications

Detection Method Radiometric
Fresh Lot Days Second Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Orexin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Metabolic Disorders, Gastrointestinal
Unit Size 10 µCi

Resources, Events & More

Resource Type File Name File Format
Technical Note Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
Flyer Using the NENSure Packaging System from PerkinElmer PDF  447 KB