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Operetta High-Content Imaging System

As scientists grapple with increasingly complex biological questions, they need to conduct larger, more complex imaging experiments. So they’re turning to the Operetta® High Content Imaging System – the ideal solution for analyzing the inner workings of healthy and diseased cells.

Part Number HH12000000
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For research use only. Not for use in diagnostic procedures.

Detail Information

Introducing the New Operetta CLS™ High-Content Analysis System

Whether you are performing assay development, genome-wide siRNA, compound screens or looking at a few samples in great detail, and whether you are using 3D disease models, primary cells, stem cells, live or fixed cells, the Operetta High Content Imaging System delivers all the features you need to generate unbiased, statistically significant data to move your research forward.

And it’s so simple to use that even newcomers to high content imaging and high content analysis can be productive right away.

See your research in stunning clarity

  • Fast widefield imaging for routine applications
  • True spinning disk confocal imaging option to eliminate background, and protect live cell samples by minimizing photobleaching and phototoxicity
  • Spinning disk pinhole size optimized for good confocality across a wide range of objectives
  • Equipped with 8 position dichroic wheel for maximum excitation flexibility
  • Unsupervised automated image acquisition and autofocus for reliable high content imaging from slides to multiple plates
  • Digital Phase contrast for imaging and segmentation of cells that have not been fluorescently labeled
  • High numerical aperture objectives give exceptional images for higher quality data and more reliable results
  • Low and high magnification plus a large field of view allows you to look at the whole well and choose an area of interest for detailed analysis
  • Get better results from your Operetta system with our microplates for high content imaging, such as the CellCarrier Ultra 384-well microplates designed for optimal performance in high content imaging applications and our CellCarrier Spheroid ULA microplates for imaging 3D models
  • Expert, global service and applications support from our dedicated team of lab- and field-based application specialists, plus an exclusive HCS support portal

Say Hello to Harmony and Goodbye to Bias

  • Intuitive Harmony® High Content Imaging and Analysis Software makes it easy for biologists to turn their biology into unbiased quantitative data
  • Developed based on many years of experience in high content analysis by our expert team with regular updates
  • Easily set up assays, automate experiments, analyze data and store, retrieve and present results
  • Intuitive plate wizard for even simpler set up of new plate types - automatically detects the important parameters plate bottom height and plate bottom thickness
  • Analysis templates for a range of common applications get new users productive with high content analysis right away
  • User-configurable image analysis building blocks for easy creation of customized high content analysis applications
  • STAR analysis provides a more detailed analysis of cellular morphology for accurate differentiation of cellular phenotypes
  • Texture analysis for applications where intensity and morphology are not suitable or do not deliver robust readout and reproducible results
  • Transfer and view data from any computer that has an installation of the Harmony software
  • Cell tracking lets you see temporal changes of biological systems and study cell dynamics in 2D
  • NEW: Advanced building blocks for easier analysis of complex applications such as FRET
  • NEW: Improved memory management for quicker processing – up to 3 times faster than Harmony 3.5
  • New: XYZ View shows an xy-, xz- and yz-section through an image stack of a thick sample e.g. microtissues

Flexibility and ease for all your applications

  • Suitable for a wide range of fixed and live cell applications
  • Live cell chamber option to maintain environmental conditions (temperature, CO2) to protect your live cell samples
  • Kinetic capabilities for carrying out time course experiments for a better understanding of cellular dynamics
  • Integrates with our robotic automation platforms for a fully automated solution.

Assay Groups

Whichever assay you are working on, the Operetta High Content Imaging System offers a solution:

  • Apoptosis
  • Cell Cycle
  • Cell Differentiation
  • Cell Migration
  • Cell Proliferation
  • Cell Shape Changes
  • Cytoskeletal Rearrangement
  • Cytotoxicity
  • Fluorescence in situ hybridization (FISH)
  • Lipid Droplet Analysis
  • Neurite Outgrowth
  • Protein Expression
  • Receptor Activation
  • RNAi Screening
  • Signaling Pathway Analysis
  • Transcription Factor

Visit our support portal


21 CFR Part 11 Compatible No
Automation Compatible Yes
Detection Method Transmission, Fluorescence
Interface Ethernet
Light Source Xenon
Portable No
Product Brand Name Operetta
Warranty Yes
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