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Nuance FX Multiplex Biomarker Imaging System

The Nuance® FX multiplex biomarker imaging system is specifically tailored to meet the majority of all brightfield and fluorescence microscopy imaging applications.

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Flexible bandwidth multispectral microscopy. The Nuance® FX multiplex biomarker imaging system is specifically tailored to meet the majority of all brightfield and fluorescence microscopy imaging applications. The system utilizes an optimized, high-throughput tunable filter distinctly matched to the bandwidths of common molecular markers. This solid-state filter is electronically switchable to maximize either sensitivity or throughput, enabling the Nuance FX to provide either chromogenic or fluorescence-based imaging. Nuance acquisition software incorporates easy to use tools for building custom spectral libraries, as well as powerful unmixing and analysis algorithms allowing spectral characterization and quantitation for each of the multi-labeled components in an image. inForm advanced image analysis software is also an available option for rapid analysis of targeted tissues and batch processing of user-specified regions across multiple images.

Disclaimer: For research use only. Not for use in diagnostic procedures.


21 CFR Part 11 Compatible No
Detection Method Fluorescence, Brightfield
Interface USB 2.0
Light Source Na
Maximum Temperature 28 °C
Optical Imaging Classification Brightfield, Fluorescence
Portable Yes
Product Brand Name Nuance
Research Areas Cancer Research

Resources, Events & More

All (16)
Resource Type File Name File Format
Brochure Nuance Multispectral Imaging Systems PDF 3 MB
Product Note inForm: Advanced Image Analysis Software PDF 8 MB
White Paper Autofluorescence removal, multiplexing and automated analysis methods for in vivo fluorescence imaging PDF 1 MB
Application Note Spectral Imaging for Separation of Fluorescent Signals from Autofluorescence PDF 1 MB
Data Sheet Selected References: Nuance Imaging Systems for Fluorescence & Brightfield Microscopy PDF 63 KB
Poster Assessing Graft Rejection by Automated C4d and CD34 Quantitation and Co-Localization PDF 972 KB
Poster Cellular context in epigenetics: Quantitative multicolor imaging and automated per-cell analysis of miRNAs and their putative targets PDF 1 MB
Poster Phenotyping TILs in situ: Automated Enumeration of Intra- and Extra-Follicular FOXP3+ Regulatory T Cells in Follicular Lymphoma PDF 1 MB
Poster Standardized Methods for Investigating the Intra-tumor Heterogeneity of HER2 in FFPE Breast Cancer Specimens Utilizing the Vectra system, inForm and AQUA® technology PDF 1 MB
Case Study Success Story: Chromogenic Microscopy PDF 682 KB
Case Study Success Story: Fluorescence Microscopy PDF 456 KB
E-book Download Phenoptics Research Solutions E-book Link
Poster Evaluation Of Tumor Immune Infiltrate as a Determinant of Response to Neo-Adjuvant Lapatinib Link
Scientific Paper NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Link
Software Downloads Click here to download latest software Link
Webinar Using multiplexed IHC to Effectively Navigate the Hidden Clues of the Immunological Microenvironment Link