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Neutrophil Elastase 680 FAST Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 

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NEV11169 663.00 USD

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Overview

Neutrophil Elastase 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. 

Neutrophil Elastase 680 FAST is a neutrophil elastase activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells. Neutrophil elastase is a key protease involved in acute lung injury, acute respiratory distress syndrome, as well as many other inflammatory processes such as emphysema, cystic fibrosis, COPD, wound healing, rheumatoid arthritis, ischemia-reperfusion and many others. 

Neutrophil Elastase 680 FAST fluorescent imaging agent is a selective neutrophil elastase-activatable agent designed for imaging of this serine protease both in vitro and in vivo. The half-life in plasma of Neutrophil Elastase 680 FAST is 4 hours.

Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.

Specifications

Fluorescent Agent Type Activatable
Optical Imaging Classification Fluorescence Imaging
Shipping Condition Blue Ice
Therapeutic Area Inflammation
Unit Size 1 Vial (10 doses)
Wave Length 680 nm

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