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NAAG, [Glutamate-3,4-3H]-, 50µCi (1.85MBq)

NAAG radioligand tritiated at the 3,4 position. NAAG is a peptide neurotransmitter that activates the metabotropic glutamate receptor type 3.

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NET1082050UC
50 µCi
1294.00 USD
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NET1082250UC
250 µCi
2822.00 USD
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Detail Information

NAAG is a peptide neurotransmitter that actives the metabotropic glutamate receptor type 3. It is the third most commonly found neurotransmitter found in the mammalian nervous system. Its role as a potential therapeutic target has been investigated in areas such as pain perception, ALS and schizophrenia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1082:

  1. Xiaojun Xu, David D Dickey, Shi-Jie Chen, Paloma H Giangrande. Structural computational modeling of RNA aptamers. Methods. July 2016. Volume 102, pages 175-179.
  2. Tomas Knedlik, Vaclav Navratil, Viktor Vik, Dalibor Pacik, Pavel Sacha, Jan Konvalinka. Detection and quantifitation of glutamate caroxypeptidase II in human blood. The Prostate. May 2014. Volume 74, Issue 7, pages 768-780.
  3. Justin P Dassie, Luiza I Hernandez, Gregory S Thomas, Matthew E Long, William M Rockey, Craig A Howell, Yani Chen, Frank J Hernandez, Xiu Ying Liu, Mary E Wilson, Lee-Ann Allen, Daniel A Vaena, David K Meyerholz, Paloma H Giangrande. Targeted Inhibition of Prostate Cancer Metastass with rNA Aptamer to Porstat-specific Membrane Antigen. Molecular Therapy. November 2014. Volume 22, Issue 11, pages 1910-192

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 304.2
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Blue Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 50 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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