Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
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MMPSense 750 FAST is an activatable fluorescent imaging agent comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection.
MMPSense 750 FAST is a matrix metalloproteinase (MMP) activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related MMP’s. Activation can occur by a broad range of MMP’s including MMP 2, 3, 7, 9, 12, and 13.
MMP activity is involved in many disease-related processes including cancer progression, invasion and metastasis, rheumatoid arthritis, pulmonary diseases and areas of cardiovascular disease. MMPSense 750 FAST may be used to monitor the progression of these diseases or to evaluate the potential therapeutic efficacy of drugs targeting the underlying mechanisms involved in these diseases.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Activatable|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||MMPSense|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Atherosclerosis, Oncology/Cancer, Arthritis, Inflammation|
|Unit Size||1 Vial (10 doses)|
|Wave Length||750 nm|
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|Resource Type||File Name||File Format|
|Brochure||FMT Fluorescence Tomography in vivo Imaging Systems||PDF 1 MB|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Technical Note||MMPSense 750 FAST (Data Sheet)||PDF 201 KB|
|Technical Note||MMPSense 750 FAST (Protocol)||PDF 257 KB|
|Poster||Fluorescence tomographic imaging of efficacy & toxicity following acute 5-FU treatment of HT29 cells||PDF 2 MB|
|Poster||In Vivo Quantification of Integrin-Targeted and Protease-Activated Imaging Agents inResponse to Anti-Angiogenic Therapy using Quantitative Fluorescence Tomography Near Infrared-Labeled Agent and Fluorescence Molecular Tomography (FMT)||PDF 385 KB|
|Poster||Non-Invasive Quantitative Tomography of Disease Progression and Therapeutic Response||PDF 581 KB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|
|Webinar||In vivo imaging of drug-induced liver injury using NIR fluorescent imaging agents - View On Demand||Link|