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Iodo-Melatonin, 2-[125I], 50µCi

Melatonin, labeled with 125I. Melatonin binds and activates melatonin receptors, a class of GPCRs that are potential drug targets for circadian rhythm sleep disorders and depression.

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Part Number Unit Size List Price Your Price Quantity
NEX236050UC 50 µCi 988.00 USD
NEX236100UC 100 µCi 1611.00 USD
NEX236250UC 250 µCi 2498.00 USD
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Overview

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX236:

  1. O'Callaghan, D., Sweeney, T., Taylor, L., Roblot, G., Wylde, R. (1999), Effect of immunization against melatonin on prolactin concentrations and the timing of reproductive transitions in ewes. Domest Anim Endocrinol, 16 (4): 207-217.
  2. Finocchiaro, L.M., Polack, E., Nahmod, V.E., Glikin, G.C. (1995), Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sci, 57 (11): 1097-1110.

Specifications

Concentration 236 µCi
Detection Method Radiometric
Fresh Lot Days Second Monday of odd months
Label Position Nominally Labeled
Molecular Weight 356.3
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Melatonin
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 50 µCi

Resources, Events & More

Resource Type File Name File Format
Technical Note Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
Flyer Using the NENSure Packaging System from PerkinElmer PDF  447 KB