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MCP-1,[125I]- labeled, Bolton-Hunter Labeled, 25µCi

Monocyte chemoattractant protein 1 (MCP-1; CCL2), labeled with 125I. MCP-1 is a cytokine released by tumor cells that binds chemokine receptor 2 (CCR2).

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Unit Size
List Price
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NEX332005UC
5 µCi
733.00 USD
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NEX332025UC
25 µCi
1728.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX332:

  1. Banisadr, G., Gosselin, R.-D., Mechighel, P., Rostène, W., Kitabgi, P. and Mélik Parsadaniantz, S. (2005), Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: Functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J. Comp. Neurol., 492: 178–192.
  2. Bonini, J.A., Martin, S.K., Dralyuk, F., Roe, M.W., Philipson, L.H., Steiner, D.F. (1997), Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol, 16 (10): 1249-1256.

Specifications

Detection Method Radiometric
Fresh Lot Days First Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Chemokine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Inflammation
Unit Size 25 µCi