Mantra™ quantitative pathology workstation with inForm® image analysis software enables easy visualization, quantification and phenotyping of multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research.
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Every Cancer Tells a Story If You Have the Tools To Read It.
Visualize, Analyze, Quantify and Phenotype Immune Cells In-Situ
Mantra is a compact workstation where a researcher can phenotype immune cells in situ in solid tumors using multiplexed biomarkers. Unlike existing flow cytometry and next generation sequencing methods which can phenotype and quantify immune cells in homogenized samples, Mantra similarly does this using images of FFPE tissue sections, while maintaining tissue architecture and morphology. This provides spatial information which could lead to a better understanding of the role and types of immune cells within both the tumor and the tumor microenvironment so that new cancer immunotherapy treatments may be identified and researched.
The Mantra is an integrated workstation incorporating multispectral imaging technology, novel image acquisition and inForm analysis software. It can be used with a variety of stains including PerkinElmer's Opal™ reagent kits. The Mantra system is a part of PerkinElmer’s cancer immunology portfolio which includes staining reagents, imaging systems, and image analysis software.
Visualize Immune Cell Phenotypes in the Context of Your Tissue
Many types of immune cells play a key role in cancer tumor growth. Until recently it was difficult, if not impossible, to phenotype immune cells in solid tumors while maintaining cellular spatial relationships and morphological context. Flow cytometry and next-gen sequencing can both phenotype cells, but only in disaggregated tissues, and standard pathological analyses can deliver morphology without being able to analyze complex phenotypes.
PerkinElmer’s in situ multiplexed biomarker staining methods, imaging systems, and image analysis software enable cell phenotypes to be simultaneously studied in solid tumors and their microenvironment. This capability enables the quantification of cancer-immune interactions, thus revealing which disease mechanism is at play—to help discover and validate biomarkers and providing better data to support research into potential subpopulation stratifcation methodologies.
Disclaimer: For research use only. Not for use in diagnostic procedures.
|21 CFR Part 11 Compatible||No|
|Detection Method||Fluorescence, Brightfield|
|Light Source||Metal Halide Lamp (Fl), Led (Bf)|
|Optical Imaging Classification||Brightfield, Fluorescence|
|Product Brand Name||Mantra|
|Research Areas||Cancer Research|
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|Resource Type||File Name||File Format|
|Brochure||Brochure: Phenoptics Portfolio||PDF 2 MB|
|Product Note||Product Note: Mantra Quantitative Pathology Workstation||PDF 2 MB|
|Product Note||Product Note: inForm Image Analysis Software||PDF 2 MB|
|Application Note||Application Note: Cancer Immunology Research Solution Microenvironment Landscape Analysis||PDF 3 MB|
|Product Info||Product Info: Let's Rid the World of Ribbons - Infographic||PDF 822 KB|
|E-book||Download Phenoptics Research Solutions E-book||Link|
|Guide||Link: Opal Automation User Manual, v4.0 or v5.2||Link|
|Link||Link: Multiparametric immune profiling in HPV– oral squamous cell cancer||Link|
|Scientific Paper||Publication: NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma||Link|
|Scientific Paper||Publication: Esbona, Karla, et al. "COX-2 modulates mammary tumor progression in response to collagen density." Breast Cancer Research 18.1 (2016)||Link|
|Scientific Paper||Publication: Feng, Zipei, et al. "Multispectral Imaging of T and B Cells in Murine Spleen and Tumor." The Journal of Immunology 196.9 (2016): 3943-3950||Link|
|Scientific Paper||Publication: Woods, Katherine, et al. "Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma." Journal for immunotherapy of cancer 4.1 (2016)||Link|
|Scientific Paper||Publication: Huang, Fangjin, et al. "Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET." The Journal of Pathology: Clinical Research (2016)||Link|
|Scientific Paper||Publication: Ören, Bilge, et al. "Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis." The Journal of Pathology (2016)||Link|
|Scientific Paper||Publication: Linch, Stefanie N., et al. "Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice." Proceedings of the National Academy of Sciences 113.3 (2016): E319-E327||Link|
|Scientific Paper||Publication: NEJM: PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma||Link|
|Scientific Paper||Publication: Novartis Genoptix Shows Multiplexed IHC Test Better Predicts Immunotherapy Response||Link|
|Scientific Paper||Publication: Miecnik, Bernhard, et al. "The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis." Science translational medicine 8.327 (2016)||Link|
|Scientific Poster||Poster: Optimization Strategy For Fluorescence Multiplex Immunohistochemistry Tissue Staining||Link|
|Scientific Poster||Poster: Automate Your Complete Cancer Research Workflow with Phenoptics™||Link|
|Webinars||Webcast: The Beginning of the End - Immunoprofiling Coming of Age||Link|
|Webinars||Webinar: Using multiplexed IHC to Effectively Navigate the Hidden Clues of the Immunological Microenvironment||Link|
|Webinars||Webinar: Untangling the tumor microenvironment: Illuminating the complex interactions and functions of immune cells||Link|