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Oncostatin M (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points

The LANCE® Ultra Human Oncostatin M Detection Kit is designed for detection and quantitation of human OSM in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

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Part Number Unit Size List Price Your Price Quantity
TRF1341C 500 Assay Points 773.00 USD
TRF1341M 10,000 Assay Points 10300.00 USD
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Overview

The LANCE® Ultra Human Oncostatin M Detection Kit is designed for detection and quantitation of human oncostatin M (OSM) in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

  • No-wash steps, no separation steps
  • TR-FRET technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 96-well, 384-well, and 1536-well formats

LANCE® and LANCE® (Lanthanide chelate excite) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One antibody of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light at 665 nm.

Oncostatin M, also known as OSM, is a growth factor encoded by the OSM gene in humans. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines and most closely resembles leukemia inhibitory factor (LIF) in both structure and function. The fully active 196 residue OSM is the predominant form isolated from activated monocytes and T lymphocytes, and corresponds to a glycoprotein of 28 Kda. It plays a key role in liver development, hematopoiesis, inflammation and possibly CNS development and is associated with bone formation and resorption. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells and can both inhibit and stimulate cell proliferation. OSM signals through cell surface receptors that contain the protein gp130.

Disclaimer:  For research use only. Not for use in diagnostic procedures.

Specifications

Assay Target Oncostatin M
Assay Target Class Protein
Automation Compatible Yes
Detection Method Time-Resolved Fluorescence (TRF), TR-FRET
Experimental Type In vitro
Product Brand Name LANCE Ultra
Shipping Condition Blue Ice
Target Species Human
Unit Size 10,000 Assay Points

Resources, Events & More

Resource Type File Name File Format
Brochure LANCE product listing PDF  77 KB
Application Note Quantifying Bcl-2 Expression Levels in Human Cells with LANCE Ultra TR-FRET PDF  3 MB
Flyer LANCE Ultra Biomarker Detection Kits PDF  585 KB