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IVIS SpectrumCT In Vivo Imaging System

The IVIS® SpectrumCT preclinical in vivo imaging system expands upon the versatility and advanced optical feature sets of the IVIS platform integrated with low dose microCT to support longitudinal imaging.

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The IVIS SpectrumCT enables simultaneous molecular and anatomical longitudinal studies, providing researchers with essential insights into complex biological systems in small animal models.

The constant horizontal gantry motion and the flat panel detector provide unparalleled performance for low-dose imaging and automated optical and microCT integration. The stable revolving animal platform table rotates 360° to acquire full 3D data. Multiple animals can be scanned simultaneously while maintaining an average dose per scan at about 13mGy, with a scanning and reconstruction time of less than a minute. Optical and microCT modalities can also operate independently.


Key features include:

  • Integrated optical and microCT technology
  • 3D optical tomography for fluorescence and bioluminescence
  • The industry’s most sensitive detection technology ideal for:
    • Bioluminescence
    • Multispectral fluorescence and spectral unmixing
    • Cerenkov imaging for optical radiotracer imaging
    • Low dose and ultra fast microCT
    • DyCE™ dynamic enhanced imaging for real time distribution studies of both fluorochromes or PET tracers ideal for PK/PD app

The IVIS SpectrumCT is an integrative platform that combines the full suite of IVIS optical features including Spectral Unmixing, 2D and 3D quantitative bioluminescence and fluorescence with fast and low dose CT imaging. The simple user interface along with automated co-registration, advanced visualization and analysis tools are driven by PerkinElmer’s market leading Living Image® software. The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect throughout the complete experimental time frame with both quantitative CT and optical reconstructions. Fast imaging and the ability to image multiple animals offers the throughput required to scan large cohorts of animals quickly and draw sound conclusions from your experimental data.

Disclaimer: For research use only. Not for use in diagnostic procedures.

Export Control Classification Number EAR99
Imaging Modality Optical Imaging, microCT Imaging
Optical Imaging Classification Bioluminescence imaging, Fluorescence Imaging
Portable No
Product Brand Name IVIS

Resource Library & Events

Resource Type File Name File Format
Brochure 3D Multimodality Imaging: See disease in all its dimensions PDF 2 MB
Product Note IVIS SpectrumCT (Product Note) PDF 2 MB
Product Note XGI-8 Gas Anesthesia System PDF 917 KB
Application Note Cerenkov Imaging of Radioisotopes in IVIS systems PDF 2 MB
Application Note Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V PDF 3 MB
Application Note Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000 PDF 4 MB
Technical Note Adaptive Fluorescence Background Subtraction PDF 1 MB
Technical Note AutoExposure PDF 1 MB
Technical Note Background ROI PDF 1 MB
Technical Note DLIT 1 Setup PDF 1 MB
Technical Note DLIT 3 Reconstruction PDF 3 MB
Technical Note Determine Saturation PDF 1 MB
Technical Note FLIT 1 Setup PDF 1 MB
Technical Note FLIT 3 Reconstruction PDF 2 MB
Technical Note High Resolution Images PDF 1 MB
Technical Note Image Overlay 2D PDF 472 KB
Technical Note Image Overlay 3D PDF 731 KB
Technical Note Intraperitoneal Injections PDF 189 KB
Technical Note Kinetic Analysis of Bioluminescent Sources PDF 1 MB
Technical Note Loading Groups of Images PDF 751 KB
Technical Note Optical Imaging on the IVIS SpectrumCT System: General and Technical Considerations for 2D and 3D Imaging PDF 3 MB
Technical Note Spectral Unmixing PDF 4 MB
Technical Note Subject ROI PDF 2 MB
Technical Note Transillumination 1 Setup PDF 918 KB
Technical Note Transillumination 2 Raster Scan PDF 2 MB
Technical Note Transillumination 3 Normalized PDF 802 KB
Technical Note Working with Image Math PDF 911 KB
Poster A fluorescent agent cocktail for detecting both cholestasis and hepatocellular forms of acute drug-induced liver injury PDF 3 MB
Poster Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts PDF 1 MB
Poster Fluorescence tomographic imaging of efficacy & toxicity following acute 5-FU treatment of HT29 cells PDF 2 MB
Poster Highly Sensitive Lanthanide Based Luminescent Particles for In Vivo Imaging of ROS Species in Deep Tissues PDF 701 KB
Poster In vivo fluorescent imaging of tumor bombesin and transferrin receptor expression as early indicators of sorafenib efficacy in small animal models PDF 1 MB
Poster Iterative Reconstruction Approach to Minimize Metal Artifacts in a Rotating Turntable CT System PDF 493 KB
Poster MicroCT/optical imaging sorafenib-driven increases in bone loss and inflammation in breast cancer PDF 1 MB
Poster Molecular imaging of tumor energy metabolism as an early indicator of anti-cancer drug efficacy in small animal models PDF 1023 KB
Featured Publication Note Imaging in CRISPR/Cas9 Applications PDF 443 KB
Flyer Comparison of IVIS Imaging Systems PDF 434 KB
Citations Library View peer reviewed publications using PerkinElmer's In Vivo Imaging systems Link
Software Downloads In Vivo Imaging Software Downloads Link
Video Article JoVE Video Articles Link
Webinar Application of Cerenkov Luminescence for Brown Adipose Tissue Imaging and In vivo Photochemistry - View On Demand Link
Webinar In vivo imaging of drug-induced liver injury using NIR fluorescent imaging agents - View On Demand Link
Webinar Optical and microCT Imaging of Bacteria, Viruses, and Tumors - View On Demand Link
Webinar Accelerating Therapeutic Development Through PET and Optical Preclinical Imaging - View On Demand Link
Webinar In Vivo Imaging Today and Tomorrow: How multimodal imaging is driving translational research - View On Demand Link
Webinar In Vivo Multimodal Imaging: Combining Functional and Anatomical Modalities to Enrich Your Data - View On Demand Link