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IntegriSense 645 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 

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NEV10640 663.00 USD

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Overview

Integrins are transmembrane cell surface receptors which mediate signal transduction, cell-to-cell interaction and cell-to extracellular matrix adhesion, key processes involved in angiogenesis, tumorigenesis and metastasis. Integrins have thus been hailed as clinically-relevant biomarkers of pathological conditions such as inflammation and tumor progression. The integrin avb3 is significantly upregulated in tumor cells and activated endothelial cells during neoangiogenesis. 

IntegriSense™ 645 fluorescent imaging agent is used for in vivo detection of avb3 using a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. IntegriSense 645, an integrin-targeted molecular imaging agent allows the non-invasive imaging of disease status and progression. Pairing of an integrin antagonist treatment with IntegriSense 645 provides a mechanistic biomarker approach for assessing target coverage. 

Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.

Specifications

Fluorescent Agent Type Targeted
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IntegriSense
Shipping Condition Blue Ice
Therapeutic Area Atherosclerosis, Oncology/Cancer, Angiogenesis
Unit Size 1 Vial (10 doses)
Wave Length 645 nm

Resources, Events & More

Resource Type File Name File Format
Brochure FMT Fluorescence Tomography in vivo Imaging Systems PDF 1 MB
Brochure In Vivo Imaging Agents Brochure PDF 2 MB
Application Note In Vivo Imaging of Atherosclerosis Disease Using FMT PDF 1 MB
Technical Note IntegriSense™ 645 (Data Sheet) PDF 105 KB
Citations Library View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents Link