Insulin (porcine), [¹²⁵I], 10 µCi (370 kBq), Specific Activity: 80-120 µCi (2.96-4.44 MBq)/µg

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX104:

1. Shimazu, T., Borjigin, L., Katayama, Y., Li, M., Satoh, T., Watanabe, K., Kitazawa, H., Roh, S.-g., Aso, H., Kazuo, K., Suda, Y., Sakuma, A., Nakajo, M. and Suzuki, K. (2014), Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization. Animal Science Journal, 85: 365–373.
2. Runnels, H.A., Arbuckle, J.A., Bailey, K.S. et al. (2010), Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies, Adv Therapy 27: 458-475.