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Ifenprodil, [Phenyl-3H]-, 250µCi (9.25MBq)

Ifenprodil, tritiated on the phenyl group. Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor.

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NET1089250UC
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Detail Information

Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. These receptors are glutamate receptors and ion channel proteins in nerve cells, and are potential drug targets for neurodegeneration, analgesia, memory disorders, and Parkinson's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1089:

  1. Jukka Kupila, Olli Kärkkäinen, Virpi Laukkanen, Merja Häkkinen, Hannu Kautiainen, Jari Tiihonen, Markus Storvik, [3H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study, In Psychiatry Research: Neuroimaging, Volume 231, Issue 3, 2015, Pages 197-201.
  2. Z. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells, In Neuroscience, Volume 159, Issue 4, 2009, Pages 1397-1407.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 325.5
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Glutamate
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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