5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 2-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
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|Part Number||Unit Size||List Price||Your Price||Quantity|
|NEC225250UC||250 µCi||3266.00 USD|
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5-Hydroxytryptamine (5-HT) binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NEC225:
|Label Position||Specifically Labeled|
|Product Brand Name||NEN Radiochemicals|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||CNS & Neurologic, Cardiovascular|
|Unit Size||250 µCi|
|Resource Type||File Name||File Format|
|Guide||Carbon-14 Handling Precautions||PDF 102 KB|