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Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[2-14C]-, 250µCi (9.25MBq)

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 2-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.

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Part Number Unit Size List Price Your Price Quantity
NEC225250UC 250 µCi 3266.00 USD
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Overview

5-Hydroxytryptamine (5-HT) binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEC225:

  1. Tamara Satram-Maharaj, Jennifer N.K. Nyarko, Kelly Kuski, Kelsey Fehr, Paul R. Pennington, Luke Truitt, Andrew Freywald, Kiven Erique Lukong, Deborah H. Anderson, Darrell D. Mousseau, The monoamine oxidase-A inhibitor clorgyline promotes a mesenchymal-to-epithelial transition in the MDA-MB-231 breast cancer cell line, In Cellular Signalling, Volume 26, Issue 12, 2014, Pages 2621-2632.
  2. Xia Cao, Xin-Min Li, Darrell D. Mousseau, Calcium alters monoamine oxidase-A parameters in human cerebellar and rat glial C6 cell extracts: Possible influence by distinct signalling pathways, In Life Sciences, Volume 85, Issues 5–6, 2009, Pages 262-268.
  3. N. Xu, L. Zhou, A.K. Ohlin, A. Nilsson, Role of Platelet Factor Xa in Chylomicron-Prothrombin Complexes Induced Platelet Activation, In Biochemical and Biophysical Research Communications, Volume 208, Issue 2, 1995, Pages 765-772.

Specifications

Concentration <1.0 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 266.2
Product Brand Name NEN Radiochemicals
Radioisotope C-14
Radionuclide 14C
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular
Unit Size 250 µCi

Resources, Events & More

Resource Type File Name File Format
Guide Carbon-14 Handling Precautions PDF  102 KB