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Calcium-release activated channel CRAC / SOCE (STIM1/ORAI1)

Stable recombinant PhotoScreen® cell line expressing the CRAC / SOCE channel.

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Product Number
AX-013-PCL

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Overview

PhotoScreen (Photina®) photoproteins are a kinetic luminescence technology for measuring calcium flux in cells. It is an alternative technology to fluorescent dyes being used on the FLIPR for studying GPCR targets. The large robust signal generated lets you screen for agonists, antagonists and allosteric modulators with reduced false positives.

We provide two vials of cryopreserved cells (approximately 2.5 x 106 cells/vial) with detailed product information including cell line properties, culture conditions and the pharmacological properties of the recombinant channel in functional assays (electrophysiology - whole cell voltage clamp and calcium flux luminescence assay).

All cell lines are tested for the absence of mycoplasma.

The main therapeutic interest around CRAC originates from its role in lymphocytes and mast cells, CRAC activation being a requirement for lymphocyte activation. CRAC is currently a research target for allergic disorders, autoimmune and inflammatory diseases. As Store-Operated Calcium Entry (SOCE) is a function found in all higher eukaryotic cells there are many potential therapeutic applications for CRAC regulators.

Terms and conditions apply. Some of our channels may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

Disclaimer: This product contains living cells. Some cells may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

Specifications

Assay Target Class Ion channel
Assay Target Type Cell line
Assay Validated Calcium Luminescence
Host Cell HEK293
Product Brand Name PhotoScreen
Receptor Type CRAC
Second Messenger Release Calcium flux
Shipping Condition Dry Ice
Unit Size 2 vials

Resources, Events & More

Resource Type File Name File Format
Poster PhotoScreen Luminescent Calcium Assays: Applications on the LumiLux and FLIPR(TETRA) PDF 322 KB
Poster Running an Aequorin Cell-Based Luminescent Assay on the FLIPR TETRA PDF 270 KB
Flyer Aequorin FLIPR PDF 1 MB