The GSP Neonatal 17α-OH-progesterone assay is intended for the quantitative determination of 17OHP in dried blood spot specimens as an aid in screening newborns for CAH.
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Congenital adrenal hyperplasia (CAH) is a genetic disorder and the most severe form of the disease can lead to a life threatening condition during the first weeks of life. The disease is caused by enzyme defects in steroid biosynthesis, the most frequent types being 21- and 11a-hydroxylase deficiency. These types represent 95% of CAH cases and in both, the 17a-OH progesterone (17OHP), a precursor of cortisol, is increased. The determination of 17OHP is thus a useful screening method for 95% of all CAH cases.
GSP Neonatal 17a-OH-progesterone assay:
The GSP Neonatal 17a-OH-progesterone assay is based on the competitive binding of europium-labeled 17OHP and 17OHP in the sample to 17OHP-specific antibodies. The fluorescence signal is inversely proportional to the analyte concentration in the sample.
All PerkinElmer neonatal products may not be available in all countries.
Disclaimer: US only
|Disorders||Congenital Adrenal Hyperplasia (CAH)|
|Product Brand Name||GSP®|
|Unit Size||1 Kit|
|Resource Type||File Name||File Format|
|Support Page||Newborn screening website||Link|