PerkinElmer
check quantity

GR113808,[N-methyl-3H]-

GR113808, tritiated on the N-methyl group. GR113808 acts as a selective antagonist at the 5-HT4 receptor.

You successfully added item(s) to your cart

Part Number
List Price
Your Price
Quantity
NET1152010UC
4070.00 USD
more
Buy Now

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Detail Information

GR113808 acts as an antagonist at the 5-HT4 receptor. This receptor belongs to a family of serotonin GPCRs that modulate the release of various neurotransmitters, and is a potential drug target for improving memory and cognition.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1152:

  1. Dhwanil A. Dalwadi, Seongcheol Kim, Shahnawaz M. Amdani, Zhenglan Chen, Ren-Qi Huang, John A. Schetz, Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz, In Pharmacological Research, Volume 110, 2016, Pages 10-24.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type 5-Hydroxytryptamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders, Gastrointestinal
Unit Size 10 µCi
Resources, Events & More
  • All

Brochure

Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

PDF 2 MB