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GBR 12935, [Propylene-2,3-3H]-, 250µCi (9.25MBq)

GBR 12935, tritiated at the propylene-2,3 position. GBR 12935 is a piperazine derivative that acts as a selective dopamine reuptake inhbitor.

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NET918250UC
250 µCi
2133.00 USD
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1 mCi
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Detail Information

GBR 12935 acts as an antagonist of the dopamine transporter, and is used in animal research into Parkinson's disease and dopamine pathways in the brain.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET918:

  1. Paul Berger, John D. Elsworth, Jorge Arroyo, Robert H. Roth, Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens, In European Journal of Pharmacology, Volume 177, Issues 1–2, 1990, Pages 91-94.
  2. Peter H. Andersen, J.Aas Jansen, Erik B. Nielsen, [3H]GBR 12935 binding in vivo in mouse brain: labelling of a piperazine acceptor site, In European Journal of Pharmacology, Volume 144, Issue 1, 1987, Pages 1-6.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 414.6
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine Transporter
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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