50 µCi quantities of [14C]-Citric acid are available for your research.
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ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a necessary cofactor. The ACL-dependent synthesis of acetyl-CoA is thought to be an essential step for the de novo synthesis of fatty acids and cholesterol. For this reason, inhibition of ACL has been pursued as a strategy to treat dyslipidemia and obesity.
|Label Position||Specifically Labeled|
|One Unit Contains||50 µCi|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Blue Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Unit Size||50 µCi|