Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
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BombesinRSense™ 680 targeted near infrared (NIR) fluorescent imaging agent is specific for bombesin receptors (BBRs) expressed in many types of cancer. Bombesin-like peptides and their G-protein coupled receptors have been shown to play a role in cancer and are overexpressed in a variety of tumors, including prostate, breast, lung, CNS, gastric, colon, and renal cell carcinomas.
BombesinRSense 680 comprises a 7-amino acid bombesin peptide analog, an NIR fluorophore (ex/em 665/691 nm) and a pharmacokinetic modifier to improve its plasma availability (plasma t1/2 = 30-45 min). This agent can be used to target and quantify upregulation of bombesin receptors (BBR) in vivo associated with tumor proliferation.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Targeted|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||BombesinRSense|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
|Resource Type||File Name||File Format|
|Application Note||Development of a Near Infrared Fluorescent Labeled Agent for Assessing Bombesin Receptor Expression||PDF 1 MB|
|Technical Note||BombesinRSense 680 (Protocol)||PDF 257 KB|
|Data Sheet||BombesinRSense 680 (Data Sheet)||PDF 136 KB|
|Poster||Optical imaging of bombesin and transferrin receptor expression is comparable to 18F-FDG in assessin||PDF 2 MB|