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Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]-, 1mCi (37MBq)

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.

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Part Number Unit Size List Price Your Price Quantity
NET833025UC 25 µCi 567.00 USD
NET833250UC 250 µCi 1870.00 USD
NET833001MC 1 mCi 4183.00 USD
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Overview

AMPA acts as an agonist at the AMPA receptor. This receptor is a ligand-gated ion channel and potential drug target for neurological diseases including epilepsy, migraine, and Alzheimer's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET833:

  1. Kärkkäinen, O., Kupila, J., Häkkinen, M., Laukkanen, V., Tupala, E., Kautiainen, H., Tiihonen, J., Storvik, M. (2013) AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study, Psychiatry Research: Neuroimaging, 214 (3): 429-434.
  2. Mutel, V., Trube, G., Klingelschmidt, A., Messer, J., Bleuel, Z., Humbel, U., Clifford, M. M., Ellis, G. J. and Richards, J. G. (1998), Binding Characteristics of a Potent AMPA Receptor Antagonist [3H]Ro 48-8587 in Rat Brain. Journal of Neurochemistry, 71: 418–426.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 186.2
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Glutamate
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain
Unit Size 1 mCi