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Retinoic Acid, [11,12-3H]9-cis-

9-cis-retinoic acid tritiated at the 11,12 position. It is a form of vitamin A and activates retinoic acid receptors (RARs).

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NET1151050UC 2596.00 USD
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9-cis-retinoic acid is a vitamin A derivative that binds both retinoid X receptors (RXRs) and retinoic acid receptors (RARs). These are nucelar receptors that can also act as transcription factors. 9-cis-retinoic acid is used in medicine as an anti-cancer agent, and is used topically to treat skin lesions and chronic eczema.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1151:

  1. G Allenby, M T Bocquel, M Saunders, S Kazmer, J Speck, M Rosenberger, A Lovey, P Kastner, J F Grippo, and P Chambon. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. PNAS, 1993, Vol. 90, Issue 1, pages 30-34.
  2. B F Tate, G Allenby, R Janocha, S Kazmer, J Speck, L J Sturzenbecker, P Abarzúa, A A Levin and J F Grippo. Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha. Molecular and Cellular Biology, 1994, Vol. 14, Issue 4, pages 2323-2330.


Concentration <1.0 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 300.44
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Retinoic Acid Receptors
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Angiogenesis, Metabolic Disorders, Cancer
Unit Size 50 µCi