5-hydroxytryptamine (5-HT, or serotonin) labeled with tritium. It is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions.
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5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in the central nervous system (CNS). 5-HT binds 5-HT serotonin receptors to regulate smooth muscle in the cardiovascular system and the GI tract and enhances platelet aggregation. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET1167:
|Concentration||1.0 - 10 mCi/mL|
|Label Position||Generally Labeled|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Dry Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||CNS & Neurologic|
|Unit Size||250 µCi|