Optical Imaging Technology

Enlarge Nu/Nu mice injected with 1ex105 PC3M-luc2 cells and tumor metastases were detected through bioluminescence imaging. Metastases were detected in the rib cage, lymph node (A), spinal cord and prostate (B), which was confirmed by necropsy analysis.

Optical imaging is a technology that measures light produced by biological or chemical moieties. At PerkinElmer, we’ve always viewed it as ‘window of opportunity’ for the non-invasive spatiotemporal visualization of biological phenomena inside a live animal. Optical imaging technologies rely on light producing optical reporters such as luciferase and fluorescent proteins, fluorescent dyes and conjugates. Genes encoding luciferase and fluorescent proteins can be engineered into cells (e.g., cancer cell lines and infectious disease agents) and animals (transgenic mice and rats) to enable them to produce light that can then be visualized through the tissues of a live animal using specialized imaging equipment and software designed and built by the company. These highly sensitive dual bioluminescence and fluorescence imaging systems allows significantly fewer animals to be used due to the generation of superior data and better biostatistics. With over 3500 publications in the scientific literature, our novel patented imaging technology has been widely embraced by researchers worldwide because of its industry-leading sensitivity, physiological relevance, multi-functionality, high-throughput and user-friendly detection capabilities. To date, PerkinElmers’s technology has been used predominantly to facilitate research and translational efforts in areas such as oncology, infectious disease, inflammation, neurobiology, stem cell and transplantation research, cardiovascular disease and toxicology.

With PerkinElmer’s combination of instrumentation and reagents we provide you the ability to capture quantitative datasets for a whole range of application areas. Come visit us at In Vivo University to learn about optical imaging techniques, therapeutic animal models, training opportunities, targeted probes and reagents for in vivo quantitative analysis.