The shape of a cell can change in response to many different stimuli. The rounding up of cells from an attached and spread-out state on a substrate, for example, can be observed when cells are dividing or experiencing toxic effects.
Analysis of cell spreading is relevant to screening for inhibitors of cell adherence to a substrate. Common measures of the cell shape are area, roundness and width to length ratio.
Morphology parameter ‘length’, visualized for each individual cell in a population.
Our Cell Shape Changes solutions
Drawing on many years of experience and in-depth knowledge, PerkinElmer offers solutions for every throughput, a starting point for typical cell shape change assays and unlimited possibilities for customization:
Opera High Content Screening System
- High sample throughput with multi-color parallel image acquisition and over 100,000 data points per day
Operetta Compact High Content Screening System
- High speed with large field of view and large cell number captured with every image
- Ready-made image analysis sequences for cell spreading and cell rounding and documentation on how to customize
- Morphometric parameter assessment, such as area, roundness or width/length ratio
- Unlimited possibilities for adding parameters and modifying readout
Acapella Image Analysis Software
- Morphometric parameter assessment, such as area, roundness or width/length ratio
- Image analysis sequences for cell spreading and cell rounding
- Unlimited possibilities for adding parameters and modifying readout
Columbus High Volume Data Management and Analysis System
- Enterprise level data management from assay development to high throughput screening seamlessly linking high content data, research data, in vivo imaging data, result management, screening statistics, biological and chemical data
cell::explorer Automated High Content Screening System
- Full environmental control and workstation with hand-over of plates from imager to incubator for short-term and long-term live cell assays
You may also be interested in: Live Cell Imaging.