Given the complexities associated with the biology of cancer, it is critical that investigations be designed to examine disease incidence, progression, and treatment in a variety of contexts. Conclusions drawn from stand-alone biochemical assay systems may be quite different from those gleaned from related studies in the cell or animal. PerkinElmer offers researchers a suite of enabling technologies and reagents that expand their capabilities and allow more seamless movements between in vitro and in vivo assay designs. From biochemical and cellular assay platforms for detecting post-translational modifications implicated in cellular proliferation to imaging technologies that allow tracking of disease progression in both the cell and animal, PerkinElmer provides solutions that can prove instrumental in helping investigators understand the true biology of cancer.
Technologies used in cancer research:
PerkinElmer’s first-in-class Epigenetic Screening Assays
Epigenetics research has exploded in the last several years, as evidenced by the exponential increase in published literature in this field. Rapid advances have been made in the elucidation of basic epigenetic mechanisms such as histone acetylation, histone methylation, and DNA methylation.
With these advances has also come an understanding of the critical role epigenetic modifications play in the development and progression of cancer, and an increased focus on the identification of clinical treatments for aberrant epigenetic states. Identification of modifiers of epigenetic enzyme activity has been the central focus of drug discovery efforts, yet such research has been hampered by limitations of available technologies as well as a lack of high quality reagents.
PerkinElmer has now developed first-in-class epigenetic research tools built upon its proprietary homogeneous assay platforms, LANCE Ultra and AlphaLISA. Together, these epigenetic assay systems offer a combination of specificity, sensitivity, and throughput that other assay methods lack, all completely validated specifically for drug discovery research. Our ever-expanding portfolio of research tools currently offers validated assays for specific detection of the following marks:
More validated assay kits coming soon!
- H3K4 unmodified