PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Product Type
  • Consumables (2)
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  • Reagents (536)
Target Species
  • Human (10)
Application
  • cAMP (26)
  • Drug Discovery & Development (338)
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  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
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Therapeutic Area
  • Angiogenesis (27)
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Product Brand Name
  • AequoScreen (2)
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Color
  • White (4)
Coating Treatment
  • Anti-mouse antibody (2)
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  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (252)
  • Time-Resolved Fluorescence (TRF) (4)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
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  • Insulin-like Growth Factor (1)
  • Interleukin (1)
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  • Norepinephrine (2)
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  • Oxytocin (2)
  • Peptide P518 (1)
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  • Potassium (2)
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  • Prolactin Releasing Peptide (2)
  • Prostanoid (9)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
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  • SK channels (1)
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  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Assay Validated
  • Binding (211)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (5)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (54)
  • Inositol Phosphate (15)
Sample Type
  • Enzyme (38)
Radioisotope
  • C-14 (6)
  • H-3 (112)
  • I-125 (78)
  • S-35 (1)
Radionuclide
  • 125I (78)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (111)
Fluorophore
  • Eu-N1-ITC (2)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (98)
  • Specifically Labeled (92)
  • Uniformly Labeled (1)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (181)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Automation Compatible
  • No (20)
  • Yes (44)
Concentration
  • 1 mCi/mL (4)
  • 1.0 - 10 mCi/mL (59)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Experimental Type
  • In vitro (4)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (135)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Length
  • 51-100 (6)
Number of Wells
  • 96 (4)
Volume
  • 0-50 (45)
  • 51-100 (1)
  • 201-250 (58)

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
Adenosine 5 Triphosphate 250 µCi

GABAPENTIN [3H]

Tritiated gabapentin (Neurontin). Gabapentin is a medication used to treat epilepsy, and has been shown to cross membrane lipid barriers via system L-amino acid transporters and bind to voltage-gated calcium channels in the central nervous system. This product has a scheduled release for the third Monday in February and September.
List Price : 4685.00 EUR
PerkinElmer

Membrane Target Systems: Calcitonin CGRP1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
Receptor-expressing cell lines

ValiScreen Nociceptin NOP (ORL1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

CGS 21680, [Carboxyethyl-3H(N)]

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.
Price Range : 1610.00 EUR - 3883.00 EUR
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 823.00 EUR
PerkinElmer

Membrane Target Systems: Dopamine D1 (human) membrane preparation, in L cells cells. 400 Units.

Cell membranes prepared from L cells stably-transfected with human dopamine D1 receptor, 400 units.
List Price : 823.00 EUR
PerkinElmer

Protein A YSI 500 MG

Protein A-coated SPA beads, for capturing antibodies in proximity-based radiometric scintillation assays.
List Price : 760.00 EUR

UniFilter-96 GF/C, White 96-well Barex Microplate with 1.2 µm poresize GF/C filter

GF/C glassfibre filter-bottom 96-well microplate, for cell harvesting assays using a vacuum manifold.
List Price : 982.00 EUR
Receptor-expressing cell lines

ValiScreen Prostanoid EP2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Uncoated PS Imaging Beads, 2G

Uncoated PS SPA beads have been shown to interact with primary phosphate groups in nucleotides (e.g. ATP) and oligonucleotides, DNA, and RNA. Membrane preparations can also be coupled to the beads.
List Price : 488.00 EUR
Receptor-expressing cell lines

ValiScreen Purinergic P2Y6 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

SPIPERONE, [3H]

Tritiated Spiperone. Spiperone acts as an antagonist at Dopamine D2 and D3 receptors, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors (α adrenoreceptors).
List Price : 1662.00 EUR
Alpha Bungarotoxin

2`-Deoxycytidine-5`-triphosphate, 5-[125I] iodo-, Tetraammonium Salt

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
Price Range : 1254.00 EUR - 3136.00 EUR
PerkinElmer

Membrane Target Systems: GABA B1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1a receptor, 400 units.
List Price : 823.00 EUR
Alpha Bungarotoxin

Iodoaminopotentidine, [125I]

NEX431 [125I]-Aminopotentidine has been shown to work in receptor binding and autoradiography and is an antagonist for histamine (H2) receptors.
Price Range : 978.00 EUR - 2208.00 EUR
Adenosine 5 Triphosphate 250 µCi

AF-DX 384, [2,3-Dipropylamino-3H]-, 250µCi (9.25MBq)

AFDX-384 (BIBN-161) radioligand tritiated at the 2,3-dipropylamino position. AFDX-384 acts as a selective antagonist of muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes.
List Price : 1711.00 EUR
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-2C (e) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
List Price : 862.00 EUR
PerkinElmer

Membrane Target Systems: Neuromedin U NMU1 (FM3) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
PerkinElmer

DELFIA® L*R wash concentrate (25x), 250 mL

Wash buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 114.00 EUR
Receptor-expressing cell lines

ValiScreen Free Fatty Acid FFA1 (GPR40) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Insulin (human, recombinant), [125I]

[125I]-Insulin (h) is suitable for the use in radioimmunoassay as well as receptor binding assay. [125I]-Insulin (h) is radioiodinated with no carrier added 125I using the LPO iodination procedure and is purified by reversed phase HPLC.
Price Range : 1240.00 EUR - 2415.00 EUR
PerkinElmer

DELFIA® L*R binding buffer concentrate (10x), 250 mL

Buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 482.00 EUR
Adenosine 5 Triphosphate 250 µCi

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 500.00 EUR - 4621.00 EUR
Adenosine 5 Triphosphate 250 µCi

RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.
List Price : 2115.00 EUR
Adenosine 5 Triphosphate 250 µCi

Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5-3H(N)]-, 250µCi (9.25MBq)

DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bind the mu opioid receptor as well.
List Price : 1480.00 EUR
Receptor-expressing cell lines

ValiScreen Leukotriene BLT1 (LTB4R1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

S365057, [Tyr 125I]

NEX396 S36057 is radioiodinated with no carrier added 125I using a lactoperoxidase procedure and is purified by reversed phase HPLC.
Price Range : 1500.00 EUR - 3218.00 EUR
PerkinElmer

Membrane Target Systems: Opioid Kappa (OP2) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 741.00 EUR
Adenosine 5 Triphosphate 250 µCi

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 570.00 EUR - 4273.00 EUR
PerkinElmer

WGA PVT SPA 2G

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 3033.00 EUR
Alpha Bungarotoxin

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 772.00 EUR - 1894.00 EUR
Alpha Bungarotoxin

Vasoactive Intestinal Polypeptide (human, porcine, rat), [125I]

Vasoactive intestinal polypeptide (VIP), labeled with 125I. VIP binds vasoactive intestinal peptide receptors VPAC1 and VPAC2, a group of GPCRs that are potential drug targets for nervous and endocrine disorders and several types of cancer.
Price Range : 1098.00 EUR - 2403.00 EUR
PerkinElmer

Membrane Target Systems: Vasopressin V1a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1a receptor, in HEK-293 cells.
List Price : 823.00 EUR
Alpha Bungarotoxin

α-Dendrotoxin [125I]

NEX434 [125I]- α-Dendrotoxinsare a class of neurotoxins produced by mamba snakes that block particular subtypes of voltage-gated potassium channels in neurons. Dendrotoxins enhance the release of acetylcholine at neuromuscular junctions.
Price Range : 1205.00 EUR - 1919.00 EUR

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).
Price Range : 620.00 EUR - 4444.00 EUR
Adenosine 5 Triphosphate 250 µCi

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). This product has a scheduled lot release for the first Monday in May and November.
Price Range : 546.00 EUR - 2430.00 EUR
Adenosine 5 Triphosphate 250 µCi

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.
Price Range : 616.00 EUR - 6100.00 EUR

Butyl Bicyclophosphorothionate, Tertiary-[35S]

Tertiary-Butylbicyclophosphorothionate (TBPS), radiolabeled with S-35. TBPS is a GABAA receptor antagonist.
Price Range : 1762.00 EUR - 3111.00 EUR
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 7, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1432.00 EUR
PerkinElmer

Membrane Target Systems: Angiotensin AT2 (mouse) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
PerkinElmer

Membrane Target Systems: Calcitonin AM2 (ADM) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
PerkinElmer

Membrane Target Systems: TRH (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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