PerkinElmer
  • Research Areas
  • Applied Genomics

Long-Read Sequencing

The predominant method for large-scale population research analysis of whole-genomes has historically involved sequencing an individual genome using short-reads, and aligning to a consensus reference sequence. Shortcomings of this method include loss of haplotype knowledge, genetic phasing information, and structural variation. While short-read sequencing provides sufficient power to call single nucleotide variants (SNVs) across most of the consensus genome, a comprehensive analysis of the genome of each unique individual is not possible.

The 10x Genomics® Chromium Genome Solution uses the power of Linked-Reads, a unique data type, to tag short reads from the same high molecular weight genomic DNA fragment with molecular barcodes, thus allowing the placement of short-read information in the context of the whole genome. This unique approach resolves genetic phasing and structural variation, and detects variants in previously inaccessible and complex regions of the genome.

PerkinElmer and 10x Genomics have created an efficient, automated workflow to maximize high molecular weight gDNA extraction, sample QC, and sample prep, providing Linked-Reads sequencing capabilities for a variety of sample types including saliva, dried blood spots, blood, and plasma.

For research use only. Not for use in diagnostic procedures.

Solutions

Nucleic Acid Isolation - Research

Based on PerkinElmer patented magnetic bead technology the chemagic instruments represent ideal solutions for nucleic acid isolation in a huge variety of research market segments including but not limited to Human Genetics, Biobanking, HLA Typing, Virus and Bacteria Detection.

Benefit from flexible solutions tailored to your sample processing and throughput needs.

For Research Use Only. Not for use in diagnostic procedures.

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DNA and RNA Analysis with Microfluidics Technology

Microfluidic Electrophoresis Analysis

The LabChip® GX Touch microfluidics technology is an unparalleled electrophoresis platform that offers high sensitivity nucleic acid analysis including: gDNA and RNA integrity assessment, library preparation quality assurance, and PCR fragment sizing and quantitation. Used in many applications including cell free DNA research, CRISPR modelling, and PCR-free library preparation, the LabChip GX Touch system quantifies DNA at concentrations as low as 2pg/uL.

  • Flexible throughput - from 1 to 384 samples per run
  • Reusable chips - up to 2000 samples
  • Choice of data output - electropherogram, virtual gel and data table format
  • Easy to use software - 21 CFR Part 11 compliant and IQ/OQ installation available

For research use only. Not for use in diagnostic procedures.

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Sciclone® G3 NGS and NGSx Workstation

The Sciclone® G3 NGS and NGSx workstations area complete benchtop solution for the automated construction of up to or greater than 96 libraries per day.

Next generation sequencing (NGS) technologies are enabling science at unprecedented rates. As the cost of sequencing declines, throughput continues to increase and the number of applications for which sequencing data can be used is expanding. The Sciclone® G3 NGS and NGSx liquid handling workstation was designed for high throughput, walkaway NGS sample preparation. The deck design and intuitive interface virtually eliminate cross contamination and user error. These liquid handlers simplify the construction of up to or greater than 96 libraries per day.

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