PerkinElmer

Drug Discovery Screening Reagents

OF

Drug discovery is a complex, costly and time-consuming undertaking. For research scientists, screening potential candidates is where the journey begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our drug discovery screening reagents do just that. Whether you are doing high throughput screening or focused screening, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE® TR-FRET, DELFIA® TRF, and other assay technologies to suit you screening assay needs.

Accelerate your workflow with our drug discovery screening reagents while getting consistent, accurate and physiologically relevant results.

AlphaLISA assay principle
AlphaLISA assay principle

Alpha Technology

Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein post-translational modifications, protein:protein interactions, peptides, sugars and small molecules.

  • Ease-of-use: homogeneous, no-wash assay, with no separation steps
  • Fast: results in 3 hours for most applications
  • High sensitivity: detect down to femtogram levels of target
  • Large dynamic range: 4-5 logs
  • Compatible with many samples types: serum, plasma, cerebrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more

Choose the Alpha solution that’s right for you

  • AlphaLISA® – when running large numbers of ELISA from the same sample or working with difficult matrix, serum or plasma
  • AlphaLISA SureFire® Ultra and AlphaScreen® SureFire – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
  • AlphaPlex – for measuring more than one analyte from the same well, by using the specific wavelengths of Europium, Terbium and Samarium atoms.
  • Alpha SureFire Ultra Multiplex – for measuring two phospho-events or one phospho and a “total” protein control from the same well.
  • AlphaScreen® – perfect for studying fusion-tagged proteins or protein: protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Toolbox – when your target doesn’t have an off-the-shelf kit, the toolbox gives you everything you need to create your own. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Biomarker kits – more than 200 validated and ready to use sandwich immunoassays. Available as AlphaLISA and AlphaPlex products.
LANCE biomarker detection assay principle
LANCE biomarker detection assay principle

LANCE Ultra TR-FRET

From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.

  • No-wash/separation steps
  • Homogeneous dispense-and-read technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 384-well and 1536-well formats

LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.

DELFIA_trf
DELFIA_trf

DELFIA

DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a proven, robust immunodetection platform based on time-resolved fluorescence (TRF) detection. This detection method, coupled with the unique chemical properties of lanthanide chelates, makes DELFIA a superior alternative to conventional ELISA for research, drug discovery, and clinical applications.

DELFIA offers a combination of high sensitivity, wide dynamic range and long-lasting stability that traditional ELISA cannot match. 

Reporter gene assay
Reporter gene assay

Reporter Gene Assays

Whether your assay requires the sensitivity provided by high signal intensity, or the flexibility of an extended signal half-life, PerkinElmer provides a solution. Choose from one of three luciferase detection systems: neolite, britelite plus, or steadylite plus depending on the specific requirements of your experiment.
  • No more washing – just add your lites reagent of choice, mix, incubate, and read
  • Hassle-free storage – all lites reagents are designed for extended storage at 2-8 °C (no -20 °C storage required)
  • Odor-friendly, eliminates hood work – lites products do not contain DTT and do not have the hazards and repugnant odor typical of conventional luciferase detection systems
  • Excellent Z’ values – superior S/B ratios allow for excellent Z’ values in antagonist and agonist studies
ATPlite assay principle
ATPlite assay principle

ATP Quantitation

For fast, reliable detection of ATP for cell quantitation, ATPlite 1step and ATPlite are innovative technologies that measure cell proliferation and cytotoxicity in mammalian cells based on the detection of ATP using firefly luciferase.

ATPlite 1step – Highest sensitivity

  • True “mix and measure” continuous processing
  • Ultra high sensitivity, 3 times more light output than ATPlite
  • Short equilibrium time for faster processing
  • Signal half-life of 30 minutes

ATPlite – Convenient, extended Signal

  • 2-step format, non-separation assay for time course studies; lysate can be stored frozen and tested later
  • Quantitate from <5 cells/well
  • Prolonged equilibrium time for batch processing
  • Signal half-life of 5 hours
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"Drug Discovery Screening Reagents" 1-50 of 1370 Products and Services

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IgG4 (human) isotyping AlphaLISA Detection Kit

The AlphaLISA Human IgG4 Detection Kit is designed for detection, quantitation, and isotyping of human IgG4 in cell culture medium and non-human serum, using a homogeneous (no wash steps, no separation steps) assay. The assay shows negligible cross-reactivity with other human IgG isotypes and monkey IgG.
Price Range : 637.00 EUR - 9900.00 EUR
AlphaLISA immunoassay kits

IL-13 (porcine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for IL13 is designed for the quantitative determination of IL13 in porcine serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows minimal cross-reactivity with human IL13.
Price Range : 717.00 EUR - 10600.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-Ribosomal Protein S6 (Ser240/244) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-Ribosomal Protein S6 (Ser240/244) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
AlphaLISA immunoassay kits

Transferrin (human) AlphaLISA Detection Kit

The AlphaLISA® Human Transferrin Detection Kit is designed for detection and quantitation of human transferrin in cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 637.00 EUR - 9900.00 EUR
SureFire principle

AlphaScreen SureFire MKK3 (p-Ser189), MKK6 (p-Ser207) Assay Kit

The AlphaScreen® SureFire® p-MKK3 (Ser207) assay is a sandwich immunoassay for quantitative detection of phospho-MKK3 (phosphorylated on Ser207) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 1536.00 EUR - 16600.00 EUR

PEG IgM AlphaLISA Detection Kit

The AlphaLISA anti-PEG IgM Detection Kit is designed for the quantitative determination of anti-PEG IgM antibodies in sera using a homogeneous (no wash steps, no separation steps) assay.
Price Range : 782.00 EUR - 17500.00 EUR
AlphaLISA SureFire Ultra kits

Phospho-Cofilin (Ser3) AlphaLISA SureFire Ultra Detection Kit

The AlphaLISA® SureFire® Ultra p-Cofilin (Ser3) assay is a sandwich immunoassay for quantitative detection of phospho-cofilin (phosphorylated on Ser3) in cellular lysates using Alpha Technology.
Price Range : 504.00 EUR - 30300.00 EUR
AlphaLisa Analyte 2

IL-13 (porcine), lyophilized (AlphaLISA)

Porcine IL-13 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA IL-13 Detection Kit, but can be ordered separately.
List Price : 247.00 EUR
AlphaLISA immunoassay kits

BACE-1 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human BACE-1 enables the quantitative determination of human BACE-1 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 445.00 EUR - 9800.00 EUR
AlphaLISA immunoassay kits

IFNβ (porcine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for porcine interferon β (IFNβ) enables the quantitative determination of porcine IFNβ in serum and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 1095.00 EUR - 10600.00 EUR
AlphaLISA immunoassay kits

Testosterone AlphaLISA Detection Kit

The AlphaLISA® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 663.00 EUR - 10300.00 EUR
SureFire principle

AlphaScreen SureFire IKKb (p-Ser177/Ser181) Assay Kit

The AlphaScreen® SureFire® p-IKKα (Ser177/181) assay is a sandwich immunoassay for quantitative detection of phospho-IKKα (phosphorylated on Ser177/181) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 1536.00 EUR - 16600.00 EUR

BDNF (human) AlphaLISA Detection Kit

AlphaLISA no-wash immunoassay kit for detection and quantitation of Brain Derived Neurotrophic Factor (BDNF) in serum, cell culture supernatants, and other samples.
Price Range : 716.00 EUR - 10300.00 EUR

Human IgG-conjugated AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to human IgG (whole). These beads are intended for use in homogenous Alpha assays to capture Fc receptors.
Price Range : 795.00 EUR - 24200.00 EUR
AlphaLISA immunoassay kits

Insulin (human) AlphaLISA Detection Kit

The AlphaLISA® Human Insulin Detection Kit is designed for detection and quantitation of human insulin in cell culture supernatants, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 715.00 EUR - 10000.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-p70 S6K (Thr389) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-p70 S6K (Thr389) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit

The AlphaLISA® SureFire® Ultra p-AKT1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-AKT1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 504.00 EUR - 29200.00 EUR
AlphaLISA assay principle

IL-12 (porcine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for porcine IL-12 enables the quantitative determination of porcine interleukin-12 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 617.00 EUR - 18500.00 EUR
SureFire principle

AlphaScreen SureFire Phospho-p38 MAPK Kit

The AlphaScreen® SureFire® p-38 MAPK (Thr180/Tyr182) assay is a sandwich immunoassay for quantitative detection of phospho-p38 MAPK (phosphorylated on Thr180/Tyr182) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 1701.00 EUR - 18200.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-STAT4 (Tyr693) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-STAT4 (Tyr693) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR

IL-13 (bovine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for bovine IL-13 enables the quantitative determination of bovine interleukin-13 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 445.00 EUR - 9800.00 EUR

LANCE Ultra ULight™-JAK-1 (Tyr1023) Peptide

ULight™-labeled synthetic peptide derived from amino acids 1015-1027 of human Janus kinase 1 (JAK-1). The ULight-JAK-1 peptide can be phosphorylated at Tyr1023 by JAK3 and several other tyrosine kinases. Peptide sequence : CAGAGAIETDKEYYTVKD
Price Range : 345.00 EUR - 1055.00 EUR
PerkinElmer

Protein A AlphaPlex™ 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to Protein A, for use in Alpha no-wash multiplexing assays.
Price Range : 605.00 EUR - 24800.00 EUR
PerkinElmer

AlphaLISA SureFire Ultra p-p38 MAPK (Thr180/Tyr182) Lysate

Extra positive and negative control lysates for the AlphaLISA® SureFire® Ultra phospho-p38 MAPK (Thr180/Tyr182) assay.
List Price : 22.00 EUR
AlphaLisa Analyte 2

Insulin (human), lyophilized (AlphaLISA)

Human insulin, lyophilized, 0.01 IU. Human insulin is included in the AlphaLISA® human insulin kits, but can also be ordered separately as a standalone item. One vial contains an amount of human insulin sufficient for performing 10 standard curves.
List Price : 254.00 EUR
AlphaLISA immunoassay kits

Cry2A AlphaLISA Detection Kit

The AlphaLISA® Cry2A Detection Kit is designed for detection and quantitation of Cry2A in GMO seeds, leaves, and plant extracts in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 617.00 EUR - 9600.00 EUR

IL-33 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human IL-33 enables the quantitative determination of human interleukin-33 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 617.00 EUR - 14800.00 EUR

CXCL13 (mouse) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for mouse CXCL13 enables the quantitative determination of mouse C-X-C Motif Chemokine Ligand 13 in serum and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 772.00 EUR - 11500.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-IKKα (Ser176/180) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-IKKα (Ser176/180) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
AlphaLisa Analyte 2

IgG4 (human) standard (AlphaLISA)

Human IgG4 lyophilized standard, for use in AlphaLISA no-wash immunoassays. This standard is already provided in AlphaLISA human IgG4 isotyping kits, but can be ordered separately.
List Price : 244.00 EUR
LANCE Detection Kit

E cadherin (human) LANCE Ultra TR-FRET Detection Kit

Human E-cadherin standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human E-cadherin TR-FRET Detection Kit, but can also be ordered separately.
Price Range : 795.00 EUR - 10600.00 EUR

LANCE Ultra ULight™-Streptavidin

Streptavidin labeled with ULight™ dye.
Price Range : 278.00 EUR - 5500.00 EUR
britelite plus Reporter Gene Assay kit

britelite plus Reporter Gene Assay System

Our brightest reporter gene assay for quantitation of firefly luciferase in mammalian cells.
Price Range : 83.00 EUR - 4891.00 EUR
AlphaLISA immunoassay kits

FASL (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human FASL enables the quantitative determination of human FAS ligand in serum and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 804.00 EUR - 11400.00 EUR
alphascreen surefire total

AlphaScreen SureFire Akt 1/2/3 Total Assay Kit

The AlphaScreen® SureFire® Akt 1/2/3 (total) assay is a sandwich immunoassay for quantitative detection of Akt 1/2/3 in cellular lysates using Alpha Technology. The assay is an ideal system for normalizing Akt levels for experiments measuring changes in Akt phosphorylation. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 1536.00 EUR - 16600.00 EUR
AlphaLISA immunoassay kits

Mucin-16 (Ovarian carcinoma antigen CA125) (human) AlphaLISA Detection Kit

The AlphaLISA® Human Mucin-16 / Ovarian Carcinoma Antigen CA125 (CA125) Detection Kit is designed for detection and quantitation of human CA125 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1564.00 EUR - 10400.00 EUR

Anti-human IgE AlphaLISA Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-human IgE antibody. These beads can be used in conjunction with Alpha Donor beads to capture human IgE antibodies in no-wash AlphaLISA immunoassays.
Price Range : 671.00 EUR - 24800.00 EUR

FCGR1/CD64 AlphaLISA Binding Kit

This kit is designed for the detection of binding between FCGR1 (CD64) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
Price Range : 2184.00 EUR - 10900.00 EUR
AlphaLisa Analyte 2

IgG2a (mouse), lyophilized (AlphaLISA)

Mouse IgG2a lyophilized standard, for use in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA mouse IgG2a isotyping kit, but can be ordered separately.
List Price : 244.00 EUR
SureFire principle

AlphaScreen SureFire p70 S6K (p-Thr421/Ser424) Assay Kit

The AlphaScreen® SureFire® p-p70 S6K (Thr421/Ser424) assay is a sandwich immunoassay for quantitative detection of phospho-p70 S6K (phosphorylated on Thr421/Ser424) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit
Price Range : 1536.00 EUR - 16600.00 EUR
AlphaLISA immunoassay kits

Soybean Agglutinin AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for Soybean Agglutinin enables the quantitative determination of Soybean agglutinin in food products in order to detect the presence of soybean proteins. It shows negligeable cross-reactivity with other lectins from alimentary plants.
Price Range : 440.00 EUR - 10400.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-SYK (Tyr525/526) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-SYK (Tyr525/526) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-STAT5 (Tyr694/699) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-STAT5 (Tyr694/699) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
PerkinElmer

LANCE Eu-W1024 anti-FITC

Eu-W1024 labeled anti-FITC antibodies for LANCE® TR-FRET assays. The anti-FITC antibody is a purified mouse IgG2a monoclonal antibody.
Price Range : 328.00 EUR - 9200.00 EUR
Protein

IL-17A (human), lyophilized (LANCE)

Human IL-17A standard, lyophilized, for use in running standard curves in LANCE TR-FRET detection assays. This standard is already provided in the LANCE Ultra Human IL-17A Detection Kit, but can be ordered separately.
List Price : 247.00 EUR

LANCE Ultra ULight-p70 S6K (Thr389) Peptide

ULight™-labeled synthetic peptide containing the amino acid residues surrounding Thr389 of human p70 S6K. The ULight-p70 S6K peptide can be phosphorylated at Thr389 by several kinases including mTOR, COT, HGK, IKKε, IRAK1, IRAK4, MAP4K2, MINK, MST1, MST2, NEK1, NEK2, NEK6, NEK7, PEK, PLK1, and TAOK2. Phosphorylation motif: LGFTYVAP
Price Range : 258.00 EUR - 1055.00 EUR
AlphaLISA immunoassay kits

hCG (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human chorionic gonadotropin (hCG) enables the quantitative determination of hCG in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 534.00 EUR - 16000.00 EUR
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-EGF Receptor (Tyr1068) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-EGF Receptor (Tyr1068) in a multiplexed assay.
Price Range : 323.00 EUR - 19500.00 EUR
AlphaPlex Samarium immunoassay kits

AlphaPlex-645 (Sm) Human Insulin Detection Kit

The AlphaPlex™ 645 (Samarium) Human Insulin Detection Kit is designed for the quantitative determination of human insulin together with another analyte (AlphaLISA) in serum, buffered solution or cell culture medium using a homogeneous (no wash steps, no separation steps) assay.
Price Range : 474.00 EUR - 10300.00 EUR
Alpha donor antibody coated

Anti-DNP Alpha Donor Beads

Alpha Donor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 1637.00 EUR - 19100.00 EUR

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