PerkinElmer
Brief_PMS299_D.jpg

Application Note

Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

Introduction

Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.